Circadian rhythm and the per ACNGGN repeat in the mole rat, Spalax ehrenbergi

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Abstract

Individual variability in circadian locomotor activity has recently been discovered in the blind mole rat, Spalax ehrenbergi. An interesting association was found between different circadian activity types and two DNA fragments, 5.6 and 5.9 kb long, that contain the ACNGGN repeat sequence, homologous to a part of the period gene of Drosophila. Nine of 12 arrythmic animals showed the 5.6-kb band, while 13 of 17 circadian rhythmic animals had the 5.9-kb band. This repeat exists also in the brain RNA of the mole rat, apparently in higher quantities during the sleeping phase, suggesting that an unusual protein(s), composed of a poly-Th-Gly segment, affects its circadian rhythm.

Original languageEnglish
Pages (from-to)177-184
Number of pages8
JournalBehavior Genetics
Volume26
Issue number2
DOIs
StatePublished - Mar 1996

Keywords

  • ACNGGN repeat sequence
  • Drosophila period gene
  • Spalax ehrenbergi
  • Subterranean mole rats
  • circadian rhythm
  • restriction fragment length polymorphism

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics
  • Ecology, Evolution, Behavior and Systematics

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