Circadian rhythm and the per ACNGGN repeat in the mole rat, Spalax ehrenbergi

Rachel Ben-Shlomo; Uzi Ritte; Eviatar Nevo

doi:10.1007/BF02359895

Circadian rhythm and the per ACNGGN repeat in the mole rat, Spalax ehrenbergi

Rachel Ben-Shlomo, Uzi Ritte, Eviatar Nevo

Department of Evolutionary and Environmental Biology

Research output: Contribution to journal › Article › peer-review

Abstract

Individual variability in circadian locomotor activity has recently been discovered in the blind mole rat, Spalax ehrenbergi. An interesting association was found between different circadian activity types and two DNA fragments, 5.6 and 5.9 kb long, that contain the ACNGGN repeat sequence, homologous to a part of the period gene of Drosophila. Nine of 12 arrythmic animals showed the 5.6-kb band, while 13 of 17 circadian rhythmic animals had the 5.9-kb band. This repeat exists also in the brain RNA of the mole rat, apparently in higher quantities during the sleeping phase, suggesting that an unusual protein(s), composed of a poly-Th-Gly segment, affects its circadian rhythm.

Original language	English
Pages (from-to)	177-184
Number of pages	8
Journal	Behavior Genetics
Volume	26
Issue number	2
DOIs	https://doi.org/10.1007/BF02359895
State	Published - Mar 1996

Keywords

ACNGGN repeat sequence
Drosophila period gene
Spalax ehrenbergi
Subterranean mole rats
circadian rhythm
restriction fragment length polymorphism

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Genetics
Genetics(clinical)

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10.1007/BF02359895

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title = "Circadian rhythm and the per ACNGGN repeat in the mole rat, Spalax ehrenbergi",

abstract = "Individual variability in circadian locomotor activity has recently been discovered in the blind mole rat, Spalax ehrenbergi. An interesting association was found between different circadian activity types and two DNA fragments, 5.6 and 5.9 kb long, that contain the ACNGGN repeat sequence, homologous to a part of the period gene of Drosophila. Nine of 12 arrythmic animals showed the 5.6-kb band, while 13 of 17 circadian rhythmic animals had the 5.9-kb band. This repeat exists also in the brain RNA of the mole rat, apparently in higher quantities during the sleeping phase, suggesting that an unusual protein(s), composed of a poly-Th-Gly segment, affects its circadian rhythm.",

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AB - Individual variability in circadian locomotor activity has recently been discovered in the blind mole rat, Spalax ehrenbergi. An interesting association was found between different circadian activity types and two DNA fragments, 5.6 and 5.9 kb long, that contain the ACNGGN repeat sequence, homologous to a part of the period gene of Drosophila. Nine of 12 arrythmic animals showed the 5.6-kb band, while 13 of 17 circadian rhythmic animals had the 5.9-kb band. This repeat exists also in the brain RNA of the mole rat, apparently in higher quantities during the sleeping phase, suggesting that an unusual protein(s), composed of a poly-Th-Gly segment, affects its circadian rhythm.

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KW - Spalax ehrenbergi

KW - Subterranean mole rats

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KW - restriction fragment length polymorphism

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Circadian rhythm and the per ACNGGN repeat in the mole rat, Spalax ehrenbergi

Abstract

Keywords

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