Abstract
This paper presents a rigorous and accurate modeling tool for ciliary motion. The hydrodynamics analysis, originally suggested by Lighthill (1975), has been modified to remove computational problems. This approach is incorporated into a moment-balance model of ciliary motion in place of the previously used hydrodynamic analyses, known as Resistive Force Theory. The method is also developed to include the effect of a plane surface at the base of the cilium, and the effect of the flow fields produced by neighboring cilia. These extensions were not possible with previous work using the Resistive Force Theory hydrodynamics. Performing reliable simulations of a single cilium as well as modeling multicilia interactions is now possible. The result is a general method which could now be used for detailed modeling of the mechanisms for generating ciliary beat patterns and patterns of metachronal interactions in arrays of cilia. A computer animation technique was designed and applied to display the results.
| Original language | English |
|---|---|
| Pages (from-to) | 1045-1058 |
| Number of pages | 14 |
| Journal | Biophysical Journal |
| Volume | 63 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1992 |
| Externally published | Yes |
Bibliographical note
Funding Information:The research was supported by the Fund for Promotion of Research at the Technion, Israel Institute of Technology, and by a grant from the Basic Research Foundation, The Israel Academy of Sciences and Hu- manities.
ASJC Scopus subject areas
- Biophysics