Chronic ethanol consumption and withdrawal affects mitochondrial benzodiazepine receptors in rat brain and peripheral organs

Miri Bidder; Ronit Weizman; Fuad Fares; Ilana Grel; Moshe Gavish

doi:10.1016/0006-2952(92)90534-P

Chronic ethanol consumption and withdrawal affects mitochondrial benzodiazepine receptors in rat brain and peripheral organs

Miri Bidder, Ronit Weizman, Fuad Fares, Ilana Grel, Moshe Gavish

Research output: Contribution to journal › Article › peer-review

Abstract

Ethanol administration to rats for 30 days resulted in a significant decrease (-28%; P< 0.05) in the density of mitochondrial benzodiazepine receptors (MBR) in the olfactory bulb. The reduction in [³H]PK 11195 binding persisted 24 hr after cessation of alcohol and had returned to normal values when measured 4 days later. Alterations were confined to this brain region and were not detected in the cerebral cortex, cerebellum or hippocampus. [³H]PK 11195 binding was elevated in the liver (100%; P<0.01), heart (43%; P< 0.01) and testis (27%; P<0.05) 30 days following ethanol consumption and this persisted for 1 and 4 days after abrupt withdrawal. A transitory decrease (-20%; P<0.05) in MBR density was observed in the adrenal gland following 30 days of alcohol ingestion, but disappeared during withdrawal. The alterations in these receptors may be relevant to the cellular damage or dysfunction induced by chronic exposure to ethanol.

Original language	English
Pages (from-to)	1335-1339
Number of pages	5
Journal	Biochemical Pharmacology
Volume	44
Issue number	7
DOIs	https://doi.org/10.1016/0006-2952(92)90534-P
State	Published - 6 Oct 1992
Externally published	Yes

Bibliographical note

Funding Information:
Acknowledgements-Thisw ork was supportedi n part by Grant 26-90 (to M.G.) from the Israel Institute for Psychobiology-the CharlesE . Smith Family Foundation. We thankR uthS ingerf or typinga nde ditingt hem anuscript. This study is submitted in partial fulfillment of the requirementsfo r the D.Sc. degreeo f M. Bidder at the Technion-IsraelI nstituteo f Technology.

ASJC Scopus subject areas

Biochemistry
Pharmacology

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10.1016/0006-2952(92)90534-P

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title = "Chronic ethanol consumption and withdrawal affects mitochondrial benzodiazepine receptors in rat brain and peripheral organs",

abstract = "Ethanol administration to rats for 30 days resulted in a significant decrease (-28%; P< 0.05) in the density of mitochondrial benzodiazepine receptors (MBR) in the olfactory bulb. The reduction in [3H]PK 11195 binding persisted 24 hr after cessation of alcohol and had returned to normal values when measured 4 days later. Alterations were confined to this brain region and were not detected in the cerebral cortex, cerebellum or hippocampus. [3H]PK 11195 binding was elevated in the liver (100%; P<0.01), heart (43%; P< 0.01) and testis (27%; P<0.05) 30 days following ethanol consumption and this persisted for 1 and 4 days after abrupt withdrawal. A transitory decrease (-20%; P<0.05) in MBR density was observed in the adrenal gland following 30 days of alcohol ingestion, but disappeared during withdrawal. The alterations in these receptors may be relevant to the cellular damage or dysfunction induced by chronic exposure to ethanol.",

author = "Miri Bidder and Ronit Weizman and Fuad Fares and Ilana Grel and Moshe Gavish",

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AU - Bidder, Miri

AU - Weizman, Ronit

AU - Fares, Fuad

AU - Grel, Ilana

AU - Gavish, Moshe

N1 - Funding Information: Acknowledgements-Thisw ork was supportedi n part by Grant 26-90 (to M.G.) from the Israel Institute for Psychobiology-the CharlesE . Smith Family Foundation. We thankR uthS ingerf or typinga nde ditingt hem anuscript. This study is submitted in partial fulfillment of the requirementsfo r the D.Sc. degreeo f M. Bidder at the Technion-IsraelI nstituteo f Technology.

PY - 1992/10/6

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N2 - Ethanol administration to rats for 30 days resulted in a significant decrease (-28%; P< 0.05) in the density of mitochondrial benzodiazepine receptors (MBR) in the olfactory bulb. The reduction in [3H]PK 11195 binding persisted 24 hr after cessation of alcohol and had returned to normal values when measured 4 days later. Alterations were confined to this brain region and were not detected in the cerebral cortex, cerebellum or hippocampus. [3H]PK 11195 binding was elevated in the liver (100%; P<0.01), heart (43%; P< 0.01) and testis (27%; P<0.05) 30 days following ethanol consumption and this persisted for 1 and 4 days after abrupt withdrawal. A transitory decrease (-20%; P<0.05) in MBR density was observed in the adrenal gland following 30 days of alcohol ingestion, but disappeared during withdrawal. The alterations in these receptors may be relevant to the cellular damage or dysfunction induced by chronic exposure to ethanol.

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Chronic ethanol consumption and withdrawal affects mitochondrial benzodiazepine receptors in rat brain and peripheral organs

Abstract

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