TY - JOUR
T1 - Chronic cognitive impairment following laterothalamic infarcts
T2 - A study of 9 cases
AU - Annoni, Jean Marie
AU - Khateb, Asaid
AU - Gramigna, Sandrine
AU - Staub, Fabienne
AU - Carota, Antonio
AU - Maeder, Philippe
AU - Bogousslavsky, Julien
PY - 2003/10
Y1 - 2003/10
N2 - Background: The occlusion of the lateral thalamic arteries leads to infarcts of ventrolateral thalamic nuclei, the ventroposterior nucleus, and the rostrolateral part of pulvinar, and produces hemisensory loss with or without hemiataxia. Cognitive impairment after such strokes has not been systematically studied. Objective: To determine the nature and the extent of long-lasting cognitive deficits following lateral thalamic strokes. Design: Case series. Setting: Neurology department, Lausanne University Hospital, Lausanne, Switzerland. Patients: Nine patients with hemisensory loss due to an isolated laterothalamic infarct. Main Outcome Measures: Three to 6 months after stroke onset, standard neuropsychologic evaluation, including testing of language, ideomotor and constructive praxis, visual gnosis, spatial attention, learning abilities, and executive functions. Results: Six of 9 patients showed some degree of cognitive impairment. Executive functions tasks, particularly verbal fluency, were impaired in 5 patients (4 with right and 1 with left lesion). Learning and delayed recall in visuospatial and verbal tasks, but not in recognition, were impaired in 3 patients (2 with right and 1 with left lesion). Difficulties in visual gnosia were observed in 1 patient with right lesion while word-finding difficulties were observed in 1 patient with left lesion. Conclusions: Our observations show that while learning, naming, and gnosic difficulties fit with the classical verbal/nonverbal dichotomy (left and right hemisphere, respectively), executive dysfunctions, including verbal fluency tasks, were more dominant after right thalamic infarcts. Although the observed deficits appeared to be less severe than those generally found with dorsomedial and polar thalamic strokes, the dominance of executive dysfunction suggests that ventrolateral thalamic lesions may disrupt frontothalamic subcortical loops.
AB - Background: The occlusion of the lateral thalamic arteries leads to infarcts of ventrolateral thalamic nuclei, the ventroposterior nucleus, and the rostrolateral part of pulvinar, and produces hemisensory loss with or without hemiataxia. Cognitive impairment after such strokes has not been systematically studied. Objective: To determine the nature and the extent of long-lasting cognitive deficits following lateral thalamic strokes. Design: Case series. Setting: Neurology department, Lausanne University Hospital, Lausanne, Switzerland. Patients: Nine patients with hemisensory loss due to an isolated laterothalamic infarct. Main Outcome Measures: Three to 6 months after stroke onset, standard neuropsychologic evaluation, including testing of language, ideomotor and constructive praxis, visual gnosis, spatial attention, learning abilities, and executive functions. Results: Six of 9 patients showed some degree of cognitive impairment. Executive functions tasks, particularly verbal fluency, were impaired in 5 patients (4 with right and 1 with left lesion). Learning and delayed recall in visuospatial and verbal tasks, but not in recognition, were impaired in 3 patients (2 with right and 1 with left lesion). Difficulties in visual gnosia were observed in 1 patient with right lesion while word-finding difficulties were observed in 1 patient with left lesion. Conclusions: Our observations show that while learning, naming, and gnosic difficulties fit with the classical verbal/nonverbal dichotomy (left and right hemisphere, respectively), executive dysfunctions, including verbal fluency tasks, were more dominant after right thalamic infarcts. Although the observed deficits appeared to be less severe than those generally found with dorsomedial and polar thalamic strokes, the dominance of executive dysfunction suggests that ventrolateral thalamic lesions may disrupt frontothalamic subcortical loops.
UR - http://www.scopus.com/inward/record.url?scp=0141889836&partnerID=8YFLogxK
U2 - 10.1001/archneur.60.10.1439
DO - 10.1001/archneur.60.10.1439
M3 - Article
C2 - 14568815
AN - SCOPUS:0141889836
SN - 0003-9942
VL - 60
SP - 1439
EP - 1443
JO - Archives of Neurology
JF - Archives of Neurology
IS - 10
ER -