Chronic antagonism of the mineralocorticoid receptor ameliorates hypertension and end organ damage in a rodent model of salt-sensitive hypertension

Xiaoyan Zhou; Martin F. Crook; Wanda Sharif-Rodriguez; Yonghua Zhu; Zadok Ruben; Yi Pan; Olga Urosevic-Price; Li Wang; Amy M. Flattery; Gail Forrest; Daphne Szeto; Huawei Zhao; Sophie Roy; Michael J. Forrest

doi:10.3109/10641963.2011.566956

Chronic antagonism of the mineralocorticoid receptor ameliorates hypertension and end organ damage in a rodent model of salt-sensitive hypertension

Xiaoyan Zhou, Martin F. Crook, Wanda Sharif-Rodriguez, Yonghua Zhu, Zadok Ruben, Yi Pan, Olga Urosevic-Price, Li Wang, Amy M. Flattery, Gail Forrest, Daphne Szeto, Huawei Zhao, Sophie Roy, Michael J. Forrest

Research output: Contribution to journal › Article › peer-review

Abstract

We investigated the effects of chronic mineralocorticoid receptor blockade with eplerenone on the development and progression of hypertension and end organ damage in Dahl salt-sensitive rats. Eplerenone significantly attenuated the progressive rise in systolic blood pressure (SBP) (204 ± 3 vs. 179±3 mmHg, p < 0.05), reduced proteinuria (605.5 ± 29.6 vs. 479.7 ± 26.1 mg/24h, p < 0.05), improved injury scores of glomeruli, tubules, renal interstitium, and vasculature in Dahl salt-sensitive rats fed a high-salt diet. These results demonstrate that mineralocorticoid receptor antagonism provides target organ protection and attenuates the development of elevated blood pressure (BP) in a model of salt-sensitive hypertension.

Original language	English
Pages (from-to)	538-547
Number of pages	10
Journal	Clinical and Experimental Hypertension
Volume	33
Issue number	8
DOIs	https://doi.org/10.3109/10641963.2011.566956
State	Published - Dec 2011
Externally published	Yes

Keywords

Mineralocorticoid receptor antagonist
dahl salt-sensitive rats
end organ protection
eplerenone
hypertension

ASJC Scopus subject areas

Internal Medicine
Physiology

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10.3109/10641963.2011.566956

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Zhou, X., Crook, M. F., Sharif-Rodriguez, W., Zhu, Y., Ruben, Z., Pan, Y., Urosevic-Price, O., Wang, L., Flattery, A. M., Forrest, G., Szeto, D., Zhao, H., Roy, S., & Forrest, M. J. (2011). Chronic antagonism of the mineralocorticoid receptor ameliorates hypertension and end organ damage in a rodent model of salt-sensitive hypertension. Clinical and Experimental Hypertension, 33(8), 538-547. https://doi.org/10.3109/10641963.2011.566956

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title = "Chronic antagonism of the mineralocorticoid receptor ameliorates hypertension and end organ damage in a rodent model of salt-sensitive hypertension",

abstract = "We investigated the effects of chronic mineralocorticoid receptor blockade with eplerenone on the development and progression of hypertension and end organ damage in Dahl salt-sensitive rats. Eplerenone significantly attenuated the progressive rise in systolic blood pressure (SBP) (204 ± 3 vs. 179±3 mmHg, p < 0.05), reduced proteinuria (605.5 ± 29.6 vs. 479.7 ± 26.1 mg/24h, p < 0.05), improved injury scores of glomeruli, tubules, renal interstitium, and vasculature in Dahl salt-sensitive rats fed a high-salt diet. These results demonstrate that mineralocorticoid receptor antagonism provides target organ protection and attenuates the development of elevated blood pressure (BP) in a model of salt-sensitive hypertension.",

keywords = "Mineralocorticoid receptor antagonist, dahl salt-sensitive rats, end organ protection, eplerenone, hypertension",

author = "Xiaoyan Zhou and Crook, {Martin F.} and Wanda Sharif-Rodriguez and Yonghua Zhu and Zadok Ruben and Yi Pan and Olga Urosevic-Price and Li Wang and Flattery, {Amy M.} and Gail Forrest and Daphne Szeto and Huawei Zhao and Sophie Roy and Forrest, {Michael J.}",

year = "2011",

month = dec,

doi = "10.3109/10641963.2011.566956",

language = "English",

volume = "33",

pages = "538--547",

journal = "Clinical and Experimental Hypertension",

issn = "1064-1963",

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Zhou, X, Crook, MF, Sharif-Rodriguez, W, Zhu, Y, Ruben, Z, Pan, Y, Urosevic-Price, O, Wang, L, Flattery, AM, Forrest, G, Szeto, D, Zhao, H, Roy, S & Forrest, MJ 2011, 'Chronic antagonism of the mineralocorticoid receptor ameliorates hypertension and end organ damage in a rodent model of salt-sensitive hypertension', Clinical and Experimental Hypertension, vol. 33, no. 8, pp. 538-547. https://doi.org/10.3109/10641963.2011.566956

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AU - Zhou, Xiaoyan

AU - Crook, Martin F.

AU - Sharif-Rodriguez, Wanda

AU - Zhu, Yonghua

AU - Ruben, Zadok

AU - Pan, Yi

AU - Urosevic-Price, Olga

AU - Wang, Li

AU - Flattery, Amy M.

AU - Forrest, Gail

AU - Szeto, Daphne

AU - Zhao, Huawei

AU - Roy, Sophie

AU - Forrest, Michael J.

PY - 2011/12

Y1 - 2011/12

N2 - We investigated the effects of chronic mineralocorticoid receptor blockade with eplerenone on the development and progression of hypertension and end organ damage in Dahl salt-sensitive rats. Eplerenone significantly attenuated the progressive rise in systolic blood pressure (SBP) (204 ± 3 vs. 179±3 mmHg, p < 0.05), reduced proteinuria (605.5 ± 29.6 vs. 479.7 ± 26.1 mg/24h, p < 0.05), improved injury scores of glomeruli, tubules, renal interstitium, and vasculature in Dahl salt-sensitive rats fed a high-salt diet. These results demonstrate that mineralocorticoid receptor antagonism provides target organ protection and attenuates the development of elevated blood pressure (BP) in a model of salt-sensitive hypertension.

AB - We investigated the effects of chronic mineralocorticoid receptor blockade with eplerenone on the development and progression of hypertension and end organ damage in Dahl salt-sensitive rats. Eplerenone significantly attenuated the progressive rise in systolic blood pressure (SBP) (204 ± 3 vs. 179±3 mmHg, p < 0.05), reduced proteinuria (605.5 ± 29.6 vs. 479.7 ± 26.1 mg/24h, p < 0.05), improved injury scores of glomeruli, tubules, renal interstitium, and vasculature in Dahl salt-sensitive rats fed a high-salt diet. These results demonstrate that mineralocorticoid receptor antagonism provides target organ protection and attenuates the development of elevated blood pressure (BP) in a model of salt-sensitive hypertension.

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KW - dahl salt-sensitive rats

KW - end organ protection

KW - eplerenone

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Chronic antagonism of the mineralocorticoid receptor ameliorates hypertension and end organ damage in a rodent model of salt-sensitive hypertension

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