Children with reading difficulties show differences in brain regions associated with orthographic processing during spoken language processing

Amy S. Desroches, Nadia E. Cone, Donald J. Bolger, Tali Bitan, Douglas D. Burman, James R. Booth

Research output: Contribution to journalArticlepeer-review

Abstract

We explored the neural basis of spoken language deficits in children with reading difficulty, specifically focusing on the role of orthography during spoken language processing. We used functional magnetic resonance imaging (fMRI) to examine differences in brain activation between children with reading difficulties (aged 9-to-15 years) and age-matched children with typical achievement during an auditory rhyming task. Both groups showed activation in bilateral superior temporal gyri (BA 42 and 22), a region associated with phonological processing, with no significant between-group differences. Interestingly, typically achieving children, but not children with reading difficulties, showed activation of left fusiform cortex (BA 37), a region implicated in orthographic processing. Furthermore, this activation was significantly greater for typically achieving children compared to those with reading difficulties. These findings suggest that typical children automatically activate orthographic representations during spoken language processing, while those with reading difficulties do not. Follow-up analyses revealed that the intensity of the activation in the fusiform gyrus was associated with significantly stronger behavioral conflict effects in typically achieving children only (i.e., longer latencies to rhyming pairs with orthographically dissimilar endings than to those with identical orthographic endings; jazz-has vs. cat-hat). Finally, for reading disabled children, a positive correlation between left fusiform activation and nonword reading was observed, such that greater access to orthography was related to decoding ability. Taken together, the results suggest that the integration of orthographic and phonological processing is directly related to reading ability.

Original languageEnglish
Pages (from-to)73-84
Number of pages12
JournalBrain Research
Volume1356
DOIs
StatePublished - 14 Oct 2010

Bibliographical note

Funding Information:
The authors would like to acknowledge the support of grants from the National Institute of Child Health and Human Development ( HD042049 ) to James R. Booth, and salary support from the Natural Sciences and Engineering Research Council of Canada (Postdoctoral Fellowship) to Amy S. Desroches. We thank Caroline Na for her assistance in the analysis of the fMRI data.

Keywords

  • Dyslexia
  • Language deficit
  • Orthography
  • Phonology
  • Spoken word processing
  • fMRI

ASJC Scopus subject areas

  • Clinical Neurology
  • Molecular Biology
  • General Neuroscience
  • Developmental Biology

Fingerprint

Dive into the research topics of 'Children with reading difficulties show differences in brain regions associated with orthographic processing during spoken language processing'. Together they form a unique fingerprint.

Cite this