Chemical composition and medicinal value of the new ganoderma tsugae var. jannieae CBS-120304 medicinal higher basidiomycete mushroom

Jannie Siew Lee Chan, Mikheil D. Asatiani, Lital Sharvit, Beny Trabelcy, Gayane S. Barseghyan, Solomon P. Wasser

Research output: Contribution to journalArticlepeer-review


In this research, the chemical composition and anticancer and antioxidant activity of the new medicinal mushroom Ganoderma tsugae var. jannieae CBS-120304 were evaluated. The chemical composition assay includes amounts of total carbohydrates and proteins, amino acids, fatty acids, micro-and macroelements, and vitamins. The investigated medicinal mushroom seemed to be a rich source of nutritional components. Mycelium accumulated more than 2-fold more total protein compared with the fruiting body and reached 37% and 16% of dry weight, respectively. Carbohydrate content in the fruiting body seemed to be conspicuously higher than in the mycelium (50% of dry weight) and reached 80% of dry weight. Quantification of the identified fatty acids indicated that, in general, palmitic acid, oleic acid, and linoleic acid were the major fatty acids. Toxic elements, such as silver, arsenic, cadmium, and mercury, were found only in trace amounts in mycelium and were not detected in the fruiting body. Furthermore, the 1,1-diphenyl-2-picrylhydrazyl free radical scavenging assay was used to evaluate antioxidant activity. The highest radical scavenging activity was 9.0 mg/mL (65.9%) by ethanol extract. In addition, mycelial extracts were tested to inhibit MCF7 breast cancer cells. Ganoderma tsugae var. jannieae ethyl acetate extract (GTEAE) extract showed high potential by inhibiting reporter activity by more than 70%. Results demonstrated that GTEAE had a strong effect on inhibitory protein κBα level in the higher concentration used (200 µg/mL), which could be compared with the effect of parthenolide. Furthermore, GTEAE demonstrated strong inhibition of IκBα phosphorylation.

Original languageEnglish
Pages (from-to)735-747
Number of pages13
JournalInternational Journal of Medicinal Mushrooms
Issue number8
StatePublished - 2015

Bibliographical note

Publisher Copyright:
© 2015 Begell House, Inc.


  • Amino acids
  • Anticancer properties
  • Carbohydrates
  • Fatty acids
  • Fruiting body
  • Ganoderma tsugae var. jannieae
  • Macro and microelements
  • Medicinal mushrooms
  • Mycelium
  • Protein
  • Vitamins

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Pharmacology
  • Drug Discovery


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