Changes in the initial slope of the QRS in ischemic patients and normal subjects undergoing scintigraphy withdipyridamole

Guy Dori; Michal Gershinsky; Simona Ben-Haim; Basil S. Lewis; Haim Bitterman

doi:10.1016/j.compbiomed.2010.09.007

Changes in the initial slope of the QRS in ischemic patients and normal subjects undergoing scintigraphy withdipyridamole

Guy Dori, Michal Gershinsky, Simona Ben-Haim, Basil S. Lewis, Haim Bitterman

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of dipyridamole (Dp) on the linear portion of the first major deflection of the QRS in human electrocardiograms (which we refer to as Fslope) was investigated in the context of myocardial perfusion imaging (MPI), in normal subjects (NS, n=19) and in patients with cardiovascular ischemia (as manifested by a positive MPI scan, n=53). In the majority of participants, Fslope decreased (84% of 19 NS and 77% of 53 patients, p=0.69). The decrease in Fslope was more pronounced in patients with ST-T deviation as compared to those without (32.6±24.5 vs. 22.4±23.1, p=0.24), and in patients vs. NS (24.9±23.5 vs. 19.6±23.4, p=0.44). A change in Fslope is a sensitive (but not specific) measure for detecting the effect of Dp on the myocardium in the setting of scintigraphy.

Original language	English
Pages (from-to)	869-875
Number of pages	7
Journal	Computers in Biology and Medicine
Volume	40
Issue number	11-12
DOIs	https://doi.org/10.1016/j.compbiomed.2010.09.007
State	Published - Nov 2010
Externally published	Yes

Keywords

Dipyridamole
ECG analysis
Electrophysiology
Myocardial ischemia
Myocardial perfusion imaging
QRS slope

ASJC Scopus subject areas

Computer Science Applications
Health Informatics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.compbiomed.2010.09.007

Cite this

@article{f6fa2cabbf9a414eae4bbc69369a1aaa,

title = "Changes in the initial slope of the QRS in ischemic patients and normal subjects undergoing scintigraphy withdipyridamole",

abstract = "The effect of dipyridamole (Dp) on the linear portion of the first major deflection of the QRS in human electrocardiograms (which we refer to as Fslope) was investigated in the context of myocardial perfusion imaging (MPI), in normal subjects (NS, n=19) and in patients with cardiovascular ischemia (as manifested by a positive MPI scan, n=53). In the majority of participants, Fslope decreased (84\% of 19 NS and 77\% of 53 patients, p=0.69). The decrease in Fslope was more pronounced in patients with ST-T deviation as compared to those without (32.6±24.5 vs. 22.4±23.1, p=0.24), and in patients vs. NS (24.9±23.5 vs. 19.6±23.4, p=0.44). A change in Fslope is a sensitive (but not specific) measure for detecting the effect of Dp on the myocardium in the setting of scintigraphy.",

keywords = "Dipyridamole, ECG analysis, Electrophysiology, Myocardial ischemia, Myocardial perfusion imaging, QRS slope",

author = "Guy Dori and Michal Gershinsky and Simona Ben-Haim and Lewis, \{Basil S.\} and Haim Bitterman",

year = "2010",

month = nov,

doi = "10.1016/j.compbiomed.2010.09.007",

language = "English",

volume = "40",

pages = "869--875",

journal = "Computers in Biology and Medicine",

issn = "0010-4825",

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T1 - Changes in the initial slope of the QRS in ischemic patients and normal subjects undergoing scintigraphy withdipyridamole

AU - Dori, Guy

AU - Gershinsky, Michal

AU - Ben-Haim, Simona

AU - Lewis, Basil S.

AU - Bitterman, Haim

PY - 2010/11

Y1 - 2010/11

N2 - The effect of dipyridamole (Dp) on the linear portion of the first major deflection of the QRS in human electrocardiograms (which we refer to as Fslope) was investigated in the context of myocardial perfusion imaging (MPI), in normal subjects (NS, n=19) and in patients with cardiovascular ischemia (as manifested by a positive MPI scan, n=53). In the majority of participants, Fslope decreased (84% of 19 NS and 77% of 53 patients, p=0.69). The decrease in Fslope was more pronounced in patients with ST-T deviation as compared to those without (32.6±24.5 vs. 22.4±23.1, p=0.24), and in patients vs. NS (24.9±23.5 vs. 19.6±23.4, p=0.44). A change in Fslope is a sensitive (but not specific) measure for detecting the effect of Dp on the myocardium in the setting of scintigraphy.

AB - The effect of dipyridamole (Dp) on the linear portion of the first major deflection of the QRS in human electrocardiograms (which we refer to as Fslope) was investigated in the context of myocardial perfusion imaging (MPI), in normal subjects (NS, n=19) and in patients with cardiovascular ischemia (as manifested by a positive MPI scan, n=53). In the majority of participants, Fslope decreased (84% of 19 NS and 77% of 53 patients, p=0.69). The decrease in Fslope was more pronounced in patients with ST-T deviation as compared to those without (32.6±24.5 vs. 22.4±23.1, p=0.24), and in patients vs. NS (24.9±23.5 vs. 19.6±23.4, p=0.44). A change in Fslope is a sensitive (but not specific) measure for detecting the effect of Dp on the myocardium in the setting of scintigraphy.

KW - Dipyridamole

KW - ECG analysis

KW - Electrophysiology

KW - Myocardial ischemia

KW - Myocardial perfusion imaging

KW - QRS slope

UR - https://www.scopus.com/pages/publications/78649328787

U2 - 10.1016/j.compbiomed.2010.09.007

DO - 10.1016/j.compbiomed.2010.09.007

M3 - Article

C2 - 20950799

AN - SCOPUS:78649328787

SN - 0010-4825

VL - 40

SP - 869

EP - 875

JO - Computers in Biology and Medicine

JF - Computers in Biology and Medicine

IS - 11-12

ER -

Changes in the initial slope of the QRS in ischemic patients and normal subjects undergoing scintigraphy withdipyridamole

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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