Changes in the density of peripheral benzodiazepine binding sites in genital organs of the female rat during the oestrous cycle

F. Fares, S. Bar-Ami, J. M. Brandes, M. Gavish

Research output: Contribution to journalArticlepeer-review

Abstract

The affinity and the density of peripheral-type benzodiazepine binding sites (PBzS) in tissues from the genital organs of female rats were studied during the oestrous cycle. When comparison PBzS density on the day of oestrus to PBzS density on the day of pro-oestrus, a significant increase was observed in the ovary (1.9-fold), oviduct (2.4-fold) and uterus (1.7-fold), but not in the kidney. Serum oestradiol also increased to a maximum on the day of pro-oestrus. The ovarian and uterine PBzS density and serum concentrations of oestradiol and progesterone were measured every 8 h between the days of dioestrus and pro-oestrus. Ovarian and uterine PBzS density increased to a maximal value at 01:00 and 09:00 h, respectively, on the day of pro-oestrus. However, a significant increase in PBzS density occurred in the ovary (P < 0.02) and uterus (P < 0.001) at 09:00 h on the day of pro-oestrus as compared to 09:00 h on the day of dioestrus. These changes were associated with an increase in serum oestradiol and progesterone concentrations. The affinity of PBzS in all tissues examined remained unaltered during the oestrous cycle. This study demonstrates that changes associated with the oestrous cycle occur in the density of PBzS in various genital organs.

Original languageEnglish
Pages (from-to)619-625
Number of pages7
JournalJournal of Reproduction and Fertility
Volume83
Issue number2
DOIs
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Obstetrics and Gynecology
  • Physiology
  • Embryology
  • Developmental Biology

Fingerprint

Dive into the research topics of 'Changes in the density of peripheral benzodiazepine binding sites in genital organs of the female rat during the oestrous cycle'. Together they form a unique fingerprint.

Cite this