TY - JOUR
T1 - Changes in resting-state connectivity following melody-based therapy in a patient with aphasia
AU - Bitan, Tali
AU - Simic, Tijana
AU - Saverino, Cristina
AU - Jones, Cheryl
AU - Glazer, Joanna
AU - Collela, Brenda
AU - Wiseman-Hakes, Catherine
AU - Green, Robin
AU - Rochon, Elizabeth
N1 - Publisher Copyright:
© 2018 Tali Bitan et al.
PY - 2018
Y1 - 2018
N2 - Melody-based treatments for patients with aphasia rely on the notion of preserved musical abilities in the RH, following left hemisphere damage. However, despite evidence for their effectiveness, the role of the RH is still an open question. We measured changes in resting-state functional connectivity following melody-based intervention, to identify lateralization of treatmentrelated changes. A patient with aphasia due to left frontal and temporal hemorrhages following traumatic brain injuries (TBI) more than three years earlier received 48 sessions of melody-based intervention. Behavioral measures improved and were maintained at the 8-week posttreatment follow-up. Resting-state fMRI data collected before and after treatment showed an increase in connectivity between motor speech control areas (bilateral supplementary motor areas and insulae) and RH language areas (inferior frontal gyrus pars triangularis and pars opercularis). This change, which was specific for the RH, was greater than changes in a baseline interval measured before treatment. No changes in RH connectivity were found in a matched control TBI patient scanned at the same intervals. These results are compatible with a compensatory role for RH language areas following melody-based intervention. They further suggest that this therapy intervenes at the level of the interface between language areas and speech motor control areas necessary for language production.
AB - Melody-based treatments for patients with aphasia rely on the notion of preserved musical abilities in the RH, following left hemisphere damage. However, despite evidence for their effectiveness, the role of the RH is still an open question. We measured changes in resting-state functional connectivity following melody-based intervention, to identify lateralization of treatmentrelated changes. A patient with aphasia due to left frontal and temporal hemorrhages following traumatic brain injuries (TBI) more than three years earlier received 48 sessions of melody-based intervention. Behavioral measures improved and were maintained at the 8-week posttreatment follow-up. Resting-state fMRI data collected before and after treatment showed an increase in connectivity between motor speech control areas (bilateral supplementary motor areas and insulae) and RH language areas (inferior frontal gyrus pars triangularis and pars opercularis). This change, which was specific for the RH, was greater than changes in a baseline interval measured before treatment. No changes in RH connectivity were found in a matched control TBI patient scanned at the same intervals. These results are compatible with a compensatory role for RH language areas following melody-based intervention. They further suggest that this therapy intervenes at the level of the interface between language areas and speech motor control areas necessary for language production.
UR - http://www.scopus.com/inward/record.url?scp=85054958872&partnerID=8YFLogxK
U2 - 10.1155/2018/6214095
DO - 10.1155/2018/6214095
M3 - Article
C2 - 29796017
AN - SCOPUS:85054958872
SN - 2090-5904
VL - 2018
JO - Neural Plasticity
JF - Neural Plasticity
M1 - 6214095
ER -