Abstract
The effects upon food intake of three dose levels of fenfluramine and amphetamine were compared in rats with bilateral or unilateral lesions of the lateral hypothalamus. Unilateral lesions produced little modulation of drug action but bilateral lesions brought about opposite effects on amphetamine and fenfluramine anorexia. At 8 weeks after operation amphetamine anorexia was significantly diminished in bilaterally lesioned animals whereas fenfluramine anorexia was significantly enhanced. Further tests carried out at 14 and 20 weeks after operation showed that amphetamine regained its anorexic potency in lesioned animals, while the enhanced potency of fenfluramine remained. The results are consistent with the belief that these two anorexic agents operate through quite separate sites and mechanisms of action.
| Original language | English |
|---|---|
| Pages (from-to) | 81-88 |
| Number of pages | 8 |
| Journal | European Journal of Pharmacology |
| Volume | 28 |
| Issue number | 1 |
| DOIs | |
| State | Published - Sep 1974 |
| Externally published | Yes |
Keywords
- Amphetamine
- Anorexia
- Fenfluramine
- Food intake
- Lateral hypothalamus
ASJC Scopus subject areas
- Pharmacology