@article{4e63ab6e71df4afbaeabf48e6200d15c,
title = "Cd8+ lymphocyte activation at human immunodeficiency virus type 1 seroconversion: Development of Hla-Dr+ Cd38 Cd8+ cells is associated with subsequent stable Cd4+ cell levels",
abstract = "Subsets of activated CD8+ lymphocytes defined by membrane expression of the activation antigens HLA-DR and CD38 were counted by three-color flow cytometry in homosexual men who subsequently became seropositive for human immunodeficiency virus type 1 (HIV). Profound CD8+ cell activation was seen in all subjects at seroconversion and 6 and 12 months later. The HLA-DR+ CD38+ CD8+ cell population, which has potent direct HIV cytotoxic T cell activity, was markedly elevated at seroconversion in all subjects. In some men, these levels remained elevated throughout the first year of infection. During the next 5 years, these men had stable CD4+ cell levels, whereas the others did not. Long-term survivors (seropositive for 9 years, >800 CD4+ cells/mm3) also had elevated levels of this subset, despite few other activated CD8+ cells. Thus, selective elevation of HLA-DR+ CD38 CD8+ cells was a marker of subsequent stable HIV disease.",
author = "\{The Multicenter AIDS Cohort Study Group\} and Giorgi, \{Janis V.\} and Ho, \{Hong Nerng\} and Karim Hirji and Chou, \{Chen Cheng\} and Hultin, \{Lance E.\} and Sheryl O{\textquoteright}rourke and Lawrence Park and Margolick, \{Joseph B.\} and John Ferbas and Phair, \{John P.\} and Saah, \{A. J.\} and H. Armenian and H. Farzadegan and N. Graham and \{Mc Arthur\}, J. and Margolick, \{J. B.\} and J. Palenicek and A. Mu{\~a}oz and D. Hoover and N. Galai and Jacobson, \{L. P.\} and L. Park and S. Piantadosi and S. Su and Phair, \{J. P.\} and K. Bauer and Chmiel, \{J. S.\} and B. Cohen and D. Variakojis and J. Wesch and Wolinsky, \{S. M.\} and R. Detels and Visscher, \{B. R.\} and I. Chen and J. Dudley and Fahey, \{J. L.\} and J. Ferbas and Giorgi, \{J. V.\} and O. Martinez-Maza and P. Nishanian and J. Taylor and J. Zack and Rinaldo, \{C. R.\} and Becker, \{J. T.\} and P. Gupta and M. Ho and L. Kingsley and L. Schrager and Kaslow, \{R. A.\} and \{Van Raden\}, \{M. J.\}",
year = "1994",
month = oct,
doi = "10.1093/infdis/170.4.775",
language = "English",
volume = "170",
pages = "775--781",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "4",
}