Caubachol mimics effects of sensory input on tyrosine phosphorylation in cortex

Kobi Rosenblum, Diego E. Berman, Shoshi Hazvi, Yadin Dudai

Research output: Contribution to journalArticlepeer-review

Abstract

We have recently shown that in the gustatory cortex of the rat, taste learning enhances protein tyrosine phosphorylation and taste memory is blocked by muscarinic antagonists. A major protein whose tyrosine phosphorylation is stimulated by taste learning in cortex is a 180 kDa synaptic glycoprotein identified as the NMDA receptor subunit 2B (NR2B). Here we report that microinjection of carbachol into the taste cortex modulates protein tyrosine phosphorylation similarly to the effect of unfamiliar taste, and that a 180 kDa protein whose tyrosine phosphorylation is enhanced in vivo by carbachol is NR2B. These data, combined with our previous findings, are in line with the hypothesis that muscarinic input plays a role in encoding new items in memory, and that tyrosine phosphorylation of NR2B is involved in this process.

Original languageEnglish
Pages (from-to)1401-1404
Number of pages4
JournalNeuroReport
Volume7
Issue number8
DOIs
StatePublished - 1996
Externally publishedYes

Keywords

  • Acetylcholine
  • Cortex
  • NMDA receptor
  • Phosphorylation
  • Taste
  • Tyrosine

ASJC Scopus subject areas

  • Neuroscience (all)

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