Abstract
The effect of propranolol on heart rate (fH) was measured in season-acclimatized pigeons. Propranolol treatment decreased fH in winter-acclimatized pigeons, accelerated fH in summer-acclimatized pigeons, but had no effect on fH in spring-acclimatized pigeons. The effect of propranolol in summer-acclimatized pigeons is opposite to that observed in mammals. Interestingly, isoproterenol produced a propranolol-like cardioacceleration in heat-acclimated pigeons. We suggest that propranolol affects fH in summer-acclimatized pigeons via two opposing routes—a direct and a peripheral indirect route. We also suggest that the cardiovascular effects of propranolol are involved in the capacity of the pigeon to evaporate water from its skin.
| Original language | English |
|---|---|
| Pages (from-to) | 1-10 |
| Number of pages | 10 |
| Journal | Journal of Basic and Clinical Physiology and Pharmacology |
| Volume | 13 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2002 |
| Externally published | Yes |
Keywords
- cardioacceleration
- isoproterenol
- propranolol
- thermoregulation
ASJC Scopus subject areas
- Physiology
- Pharmacology
- Drug Discovery
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