The effect of propranolol on heart rate (fH) was measured in season-acclimatized pigeons. Propranolol treatment decreased fH in winter-acclimatized pigeons, accelerated fH in summer-acclimatized pigeons, but had no effect on fH in spring-acclimatized pigeons. The effect of propranolol in summer-acclimatized pigeons is opposite to that observed in mammals. Interestingly, isoproterenol produced a propranolol-like cardioacceleration in heat-acclimated pigeons. We suggest that propranolol affects fH in summer-acclimatized pigeons via two opposing routes—a direct and a peripheral indirect route. We also suggest that the cardiovascular effects of propranolol are involved in the capacity of the pigeon to evaporate water from its skin.
|Number of pages||10|
|Journal||Journal of Basic and Clinical Physiology and Pharmacology|
|State||Published - 2002|
ASJC Scopus subject areas
- Drug Discovery