The treatment of neuropathic pain remains a challenge as it rarely leads to long-term relief of symptoms. We report three patients with chronic neuropathic pain, in whom acute administration of the N-methyl-D-aspartate (NMDA) receptor antagonist amantadine resulted in complete resolution of symptoms, presumably due to termination the central 'wind-up' phenomenon.
- 'wind-up' phenomenon
- N-methyl-D-aspartate receptor
- Neuropathic pain
ASJC Scopus subject areas
- Clinical Neurology
- Anesthesiology and Pain Medicine