Calcium/Calmodulin-Dependent Protein Kinase II and Eukaryotic Elongation Factor 2 Kinase Pathways Mediate the Antidepressant Action of Ketamine

Keyphrases

• Antidepressants 100%
• Ketamine 100%
• Kinase Cascade 100%
• CaMKII 100%
• EEF2 100%
• Protein Synthesis 40%
• Phosphorylation 30%
• Major Depressive Disorder 20%
• TatCN21 20%
• Mechanism of Action 10%
• Hippocampus 10%
• C57BL 10%
• Knock-in Mouse Model 10%
• Cortex 10%
• Knock 10%
• Differential Regulation 10%
• GluA1 10%
• Systemic Administration 10%
• Major Pathway 10%
• Specific Inhibitor 10%
• Threonine 10%
• Behavioral Resistance 10%
• N-methyl-D-aspartate Receptor Antagonist 10%
• Forced Swim 10%
• Inhibition Phase 10%
• Delayed Induction 10%
• CaMK 10%
• Autoinhibition 10%
• Autoactivation 10%
• Tail Suspension 10%
• Rapid-acting Antidepressant 10%
• Novelty-suppressed Feeding Test 10%

Neuroscience

• Antidepressant 100%
• Ketamine 100%
• Calcium Calmodulin Dependent Protein Kinase II 100%
• Elongation Factor 2 Kinase 100%
• Protein Biosynthesis 40%
• Major Depressive Disorder 20%
• Hippocampus 10%
• NMDA Receptor Antagonist 10%
• Threonine 10%

Pharmacology, Toxicology and Pharmaceutical Science

• Ketamine 100%
• Antidepressant 100%
• Elongation Factor 2 Kinase 100%
• Calcium Calmodulin Dependent Protein Kinase II 100%
• Major Depression 20%
• Knockout Mouse 10%
• C57BL 6 Mouse 10%
• Threonine 10%
• Systemic Administration 10%
• NMDA Receptor Antagonist 10%