BRCA1/2 mutations and FMR1 alleles are randomly distributed: A case control study

Efrat Dagan, Yoram Cohen, Adi Mory, Vardit Adir, Zvi Borochowitz, Hila Raanani, Alina Kurolap, Svetlana Melikhan-Revzin, Dror Meirow, Ruth Gershoni-Baruch

Research output: Contribution to journalArticlepeer-review

Abstract

BRCA mutation carriers were reported to display a skewed distribution of FMR1 genotypes, predominantly within the low normal range (CGG repeat number <26). This observation led to the interpretation that BRCA1/2 mutations are embryo-lethal, unless rescued by 'low FMR1 alleles'. We undertook to re-explore the distribution of FMR1 alleles subdivided into low, normal and high (<26, 26-34, and >34 CGG repeats, respectively) subgenotypes, on a cohort of 125 Ashkenazi women, carriers of a BRCA1/2 founder mutation. Ashkenazi healthy females (n=368), tested in the frame of the Israeli screening population program, served as controls. BRCA1/2 carriers and controls demonstrated a comparable and non-skewed FMR1 subgenotype distribution. Taken together, using a homogeneous ethnic group of Ashkenazi BRCA1/2 mutation carriers, we could not confirm the reported association between FMR1 low genotypes and BRCA1/2 mutations. The notion that BRCA1/2 mutations are embryo-lethal unless rescued by the low FMR1 subgenotypes is hereby refuted.

Original languageEnglish
Pages (from-to)277-279
Number of pages3
JournalEuropean Journal of Human Genetics
Volume22
Issue number2
DOIs
StatePublished - Feb 2014

Bibliographical note

Funding Information:
We acknowledge the Israeli Jack Craps foundation for funding this research.

Keywords

  • BRCA1/2
  • CGG repeats
  • FMR1 subgenotypes

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

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