Blocking Opioid Receptors in a Songbird Cortical Region Modulates the Acoustic Features and Levels of Female-Directed Singing

Sandeep Kumar, Alok Nath Mohapatra, Arvind Singh Pundir, Mukta Kumari, Uzma Din, Sudha Sharma, Atanu Datta, Vasav Arora, Soumya Iyengar

Research output: Contribution to journalArticlepeer-review

Abstract

The organization of the anterior forebrain pathway (AFP) of songbirds important for context-dependent singing is similar to that of cortical basal ganglia loops (CBG) in mammals, which underlie motor behaviors including vocalization. Since different components of the AFP express high levels of μ-opioid receptors (μ-ORs) as do CBG loops, songbirds act as model systems to study the role of opioid modulation on vocalization and the motivation to sing. The AFP in songbirds includes the cortical/pallial region LMAN (lateral magnocellular nucleus of the anterior nidopallium) which projects to Area X, a nucleus of the avian basal ganglia. In the present study, microdialysis was used to infuse different doses of the opioid antagonist naloxone in LMAN of adult male zebra finches. Whereas all doses of naloxone led to significant decreases in the number of FD (female-directed) songs, only 100 and 200 ng/ml of naloxone affected their acoustic properties. The decrease in FD song was not accompanied by changes in levels of attention toward females or those of neurotransmitters (dopamine, glutamate, and GABA) in LMAN. An earlier study had shown that similar manipulations in Area X did not lead to alterations in the number of FD songs but had significantly greater effects on their acoustic properties. Taken together, our results suggest that there are reciprocal effects of OR modulation on cortical and basal ganglia components of the AFP in songbirds.

Original languageEnglish
Article number554094
JournalFrontiers in Neuroscience
Volume14
DOIs
StatePublished - 17 Sep 2020
Externally publishedYes

Bibliographical note

Publisher Copyright:
© Copyright © 2020 Kumar, Mohapatra, Pundir, Kumari, Din, Sharma, Datta, Arora and Iyengar.

Keywords

  • acoustic features
  • cortex
  • cortico-basal ganglia loops
  • LMAN
  • opioid receptors
  • songbirds

ASJC Scopus subject areas

  • General Neuroscience

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