@inbook{fbd7881510ad4ab4ba4a20063d362d6e,
title = "Bioinformatic identification of homing endonucleases and their target sites",
abstract = "Homing endonuclease genes (HEGs) are a large, phylogenetically diverse superfamily of enzymes with high specificity for especially long target sites. The public genomic sequence databases contain thousands of HEGs. This is a large and diverse arsenal of potential genome editing tools. To make use of this natural resource, one needs to identify candidate HEGs. Due to their special relationship with a host gene, it is also possible to predict their cognate target sequences. Here I describe the HomeBase algorithm that was developed to this end. A detailed description of the computational pipeline is provided with emphasis on technical and methodological caveats of the approach.",
keywords = "HomeBase, Homing endonucleases, Homology search, Target-site prediction",
author = "Eyal Privman",
year = "2014",
doi = "10.1007/978-1-62703-968-0_2",
language = "אנגלית",
isbn = "9781627039673",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "27--35",
booktitle = "Homing Endonucleases",
}