Bi-phasic activation of the primary motor cortex by pain and its relation to pain-evoked potentials − an exploratory study

Lee Bareket Kisler, Irit Weissman-Fogel, Alon Sinai, Elliot Sprecher, Andrei V. Chistyakov, Simone Shamay-Tsoory, Nadav Moscovitz, Yelena Granovsky

Research output: Contribution to journalArticlepeer-review


The primary motor cortex (M1) is a known target for brain stimulation aimed at pain alleviation in chronic pain patients, yet the mechanisms through which analgesia occurs, and the exact pain-motor interrelations are not fully understood. We used noxious contact heat evoked potentials (CHEPs) and cortical source analysis to further explore the relevance of M1 in pain processing. Twenty-four healthy young females received brief noxious heat stimuli to their left non-dominant volar forearm, simultaneously with CHEPs recordings. Thereafter, the pain-evoked activity of M1 and a control area in the occipital cortex (OC) was analyzed and estimated using sLORETA (standardized low-resolution brain electromagnetic tomography). This analysis revealed two phases of M1 pain-evoked activation (phase 1: the peak at 261.5 ± 25.7 ms; phase 2: the peak at 381.3 ± 28.3 ms). Canonical correlations revealed that M1, but not the OC, was the main factor contributing to the relation with the CHEPs components. In detail, the activity magnitude of M1 first and second phases was related to the N2 and P2 amplitude, respectively. The latency of the second phase was associated with both N2 and P2 latencies. In relation to pain, the latency of M1’s first activity phase was positively correlated with pain ratings, suggesting pain interference to synchronized activity in M1. Our results confirm the established relevance of the primary motor cortex to pain processing.

Original languageEnglish
Pages (from-to)209-217
Number of pages9
JournalBehavioural Brain Research
StatePublished - 15 Jun 2017

Bibliographical note

Publisher Copyright:
© 2017 Elsevier B.V.


  • Canonical correlation
  • Contact heat evoked potentials (CHEPs)
  • Pain psychophysics
  • Primary motor cortex (M1)
  • Standardized low-resolution brain electromagnetic tomography (sLORETA)

ASJC Scopus subject areas

  • Behavioral Neuroscience


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