Attitudinal barriers to delivery of race-targeted pharmacogenomics among informed lay persons

Celeste Condit, Alan Templeton, Benjamin R. Bates, Jennifer L. Bevan, Tina M. Harris

Research output: Contribution to journalArticlepeer-review


Objectives: To ascertain attitudes of prospective patients relevant to the delivery of race-based pharmacogenomics. Methods: Written anonymous survey and qualitative responses in two sets of reactance format focus groups over-sampled for minority groups in urban, suburban, and rural communities conducted from February through April, 2002 [N = 104] and August through November, 2002 [N = 120]. Results: Participants do not associate "races" exclusively with continental clusters. They have incomplete knowledge of their recent ancestors (39.6% do not know all their biological grandparents). They would be highly suspicious of race-labeled drugs; with 47.5% saying they would be very suspicious of their safety and 40.6% indicating they would be very suspicious of their efficacy. A substantial minority of African-American participants (13.2%) would prefer to take the drugs designated for European Americans. Effect of discussion of race-based medicine on racial attitudes is ambiguous. Conclusions: Patient knowledge of ancestry and suspicion of race-designated drugs constitute substantial barriers that need to be incorporated in judging the likely effectiveness of race-based pharmacogenomics.

Original languageEnglish
Pages (from-to)385-392
Number of pages8
JournalGenetics in Medicine
Issue number5
StatePublished - Sep 2003
Externally publishedYes


  • Genetic discrimination
  • Pharmacogenomics
  • Race

ASJC Scopus subject areas

  • Genetics(clinical)


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