Asymmetric autocatalysis enables an improved synthesis of efavirenz

Nicka Chinkov; Aleksander Warm; Erick M. Carreira

doi:10.1002/anie.201006689

Asymmetric autocatalysis enables an improved synthesis of efavirenz

Nicka Chinkov, Aleksander Warm, Erick M. Carreira

Research output: Contribution to journal › Article › peer-review

Abstract

(Chemical Equation Presented) Priming the pump: An asymmetric autocatalytic zinc acetylide addition employs catalytic amounts of the enantiomerically pure product as part of a chiral cocktail. This new strategy enables an improved synthesis of a key precursor to efavirenz (see scheme).

Original language	English
Pages (from-to)	2957-2961
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	13
DOIs	https://doi.org/10.1002/anie.201006689
State	Published - 21 Mar 2011
Externally published	Yes

Keywords

Asymmetric catalysis
Autocatalysis
Efavirenz
Tertiary alkynols
Zinc acetylides

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.201006689

Cite this

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title = "Asymmetric autocatalysis enables an improved synthesis of efavirenz",

abstract = "(Chemical Equation Presented) Priming the pump: An asymmetric autocatalytic zinc acetylide addition employs catalytic amounts of the enantiomerically pure product as part of a chiral cocktail. This new strategy enables an improved synthesis of a key precursor to efavirenz (see scheme).",

keywords = "Asymmetric catalysis, Autocatalysis, Efavirenz, Tertiary alkynols, Zinc acetylides",

author = "Nicka Chinkov and Aleksander Warm and Carreira, \{Erick M.\}",

year = "2011",

month = mar,

day = "21",

doi = "10.1002/anie.201006689",

language = "English",

volume = "50",

pages = "2957--2961",

journal = "Angewandte Chemie - International Edition",

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publisher = "John Wiley and Sons Ltd",

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T1 - Asymmetric autocatalysis enables an improved synthesis of efavirenz

AU - Chinkov, Nicka

AU - Warm, Aleksander

AU - Carreira, Erick M.

PY - 2011/3/21

Y1 - 2011/3/21

N2 - (Chemical Equation Presented) Priming the pump: An asymmetric autocatalytic zinc acetylide addition employs catalytic amounts of the enantiomerically pure product as part of a chiral cocktail. This new strategy enables an improved synthesis of a key precursor to efavirenz (see scheme).

AB - (Chemical Equation Presented) Priming the pump: An asymmetric autocatalytic zinc acetylide addition employs catalytic amounts of the enantiomerically pure product as part of a chiral cocktail. This new strategy enables an improved synthesis of a key precursor to efavirenz (see scheme).

KW - Asymmetric catalysis

KW - Autocatalysis

KW - Efavirenz

KW - Tertiary alkynols

KW - Zinc acetylides

UR - https://www.scopus.com/pages/publications/79952658020

U2 - 10.1002/anie.201006689

DO - 10.1002/anie.201006689

M3 - Article

C2 - 21365723

AN - SCOPUS:79952658020

SN - 1433-7851

VL - 50

SP - 2957

EP - 2961

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 13

ER -

Asymmetric autocatalysis enables an improved synthesis of efavirenz

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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