Asymmetric autocatalysis enables an improved synthesis of efavirenz

Nicka Chinkov; Aleksander Warm; Erick M. Carreira

doi:10.1002/anie.201006689

Asymmetric autocatalysis enables an improved synthesis of efavirenz

Nicka Chinkov, Aleksander Warm, Erick M. Carreira

Research output: Contribution to journal › Article › peer-review

Abstract

(Chemical Equation Presented) Priming the pump: An asymmetric autocatalytic zinc acetylide addition employs catalytic amounts of the enantiomerically pure product as part of a chiral cocktail. This new strategy enables an improved synthesis of a key precursor to efavirenz (see scheme).

Original language	English
Pages (from-to)	2957-2961
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	13
DOIs	https://doi.org/10.1002/anie.201006689
State	Published - 21 Mar 2011
Externally published	Yes

Keywords

Asymmetric catalysis
Autocatalysis
Efavirenz
Tertiary alkynols
Zinc acetylides

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.201006689

Cite this

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abstract = "(Chemical Equation Presented) Priming the pump: An asymmetric autocatalytic zinc acetylide addition employs catalytic amounts of the enantiomerically pure product as part of a chiral cocktail. This new strategy enables an improved synthesis of a key precursor to efavirenz (see scheme).",

keywords = "Asymmetric catalysis, Autocatalysis, Efavirenz, Tertiary alkynols, Zinc acetylides",

author = "Nicka Chinkov and Aleksander Warm and Carreira, {Erick M.}",

year = "2011",

month = mar,

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doi = "10.1002/anie.201006689",

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AU - Warm, Aleksander

AU - Carreira, Erick M.

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KW - Asymmetric catalysis

KW - Autocatalysis

KW - Efavirenz

KW - Tertiary alkynols

KW - Zinc acetylides

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Asymmetric autocatalysis enables an improved synthesis of efavirenz

Abstract

Keywords

ASJC Scopus subject areas

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