Asymmetric autocatalysis enables an improved synthesis of efavirenz

Nicka Chinkov, Aleksander Warm, Erick M. Carreira

Research output: Contribution to journalArticlepeer-review


(Chemical Equation Presented) Priming the pump: An asymmetric autocatalytic zinc acetylide addition employs catalytic amounts of the enantiomerically pure product as part of a chiral cocktail. This new strategy enables an improved synthesis of a key precursor to efavirenz (see scheme).

Original languageEnglish
Pages (from-to)2957-2961
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number13
StatePublished - 21 Mar 2011
Externally publishedYes


  • Asymmetric catalysis
  • Autocatalysis
  • Efavirenz
  • Tertiary alkynols
  • Zinc acetylides

ASJC Scopus subject areas

  • General Chemistry
  • Catalysis


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