TY - JOUR
T1 - Association of neurodevelopmental conditions with Alzheimer’s disease and related dementias and Parkinson’s disease
AU - Rast, Jessica E
AU - Rosso, Andrea L
AU - James, Bryan D
AU - Underwood, Jack F G
AU - Bergstedt, Jacob
AU - Ahlqvist, Viktor H
AU - Grove, Jakob
AU - Fang, Fang
AU - Goldstein, Neal D
AU - Vivanti, Giacomo
AU - Levine, Stephen
AU - Nordström, Anna
AU - Schendel, Diana
AU - Lyall, Kristen
AU - Nordström, Peter
AU - Ballin, Marcel
AU - Stafford, Jean
AU - Naj, Adam
AU - Lee, Brian
AU - Consortium, the LEGENNDS
PY - 2025/12/22
Y1 - 2025/12/22
N2 - BackgroundNeurodevelopmental
conditions (NDC), including attention deficit/hyperactivity disorder
(ADHD) and autism, are associated with increased rates of
neurodegenerative diseases, including Alzheimer’s disease and related
dementias (ADRD) and Parkinson’s disease. Such associations are
unstudied in diverse populations and while controlling for a range of
important covariates. The purpose of this study was to examine the
association of ADRD and Parkinson’s disease with NDCs in a diverse
sample of adults.MethodsThis
case-control study used data from the U.S. All of Us Research Program
2018-2023 from approximately 600,000 adults in the U.S. We matched on
ADRD and Parkinson’s disease status in order to examine the association
of these conditions with NDCs.ResultsNDC
was more prevalent in ADRD cases than in non-ADRD controls (7.8% versus
2.4%) and among Parkinson’s disease cases than non-Parkinson’s disease
controls (4.5% versus 1.8%). After adjustment for sex, age, education
level, body mass index, cardiometabolic conditions, and psychiatric
conditions, individuals with ADRD had significantly higher odds of
having an NDC compared with controls (adjusted odds ratio, 2.68; 95% CI,
2.40–2.99). Similarly, Parkinson’s disease cases had 2.09 times the
odds of having an NDC as non-Parkinson’s disease controls (95% CI 1.66,
2.59) in adjusted models.ConclusionsAs
the population of individuals with NDCs ages, and more older adults
find themselves in the care of clinicians with experetise in ADRD and
Parkinson’s disease, it is imperative to understand the support needs of
this population, and to provide targets for reducing ADRD prevalence in
younger or middle adulthood.
AB - BackgroundNeurodevelopmental
conditions (NDC), including attention deficit/hyperactivity disorder
(ADHD) and autism, are associated with increased rates of
neurodegenerative diseases, including Alzheimer’s disease and related
dementias (ADRD) and Parkinson’s disease. Such associations are
unstudied in diverse populations and while controlling for a range of
important covariates. The purpose of this study was to examine the
association of ADRD and Parkinson’s disease with NDCs in a diverse
sample of adults.MethodsThis
case-control study used data from the U.S. All of Us Research Program
2018-2023 from approximately 600,000 adults in the U.S. We matched on
ADRD and Parkinson’s disease status in order to examine the association
of these conditions with NDCs.ResultsNDC
was more prevalent in ADRD cases than in non-ADRD controls (7.8% versus
2.4%) and among Parkinson’s disease cases than non-Parkinson’s disease
controls (4.5% versus 1.8%). After adjustment for sex, age, education
level, body mass index, cardiometabolic conditions, and psychiatric
conditions, individuals with ADRD had significantly higher odds of
having an NDC compared with controls (adjusted odds ratio, 2.68; 95% CI,
2.40–2.99). Similarly, Parkinson’s disease cases had 2.09 times the
odds of having an NDC as non-Parkinson’s disease controls (95% CI 1.66,
2.59) in adjusted models.ConclusionsAs
the population of individuals with NDCs ages, and more older adults
find themselves in the care of clinicians with experetise in ADRD and
Parkinson’s disease, it is imperative to understand the support needs of
this population, and to provide targets for reducing ADRD prevalence in
younger or middle adulthood.
U2 - 10.1093/gerona/glaf281
DO - 10.1093/gerona/glaf281
M3 - Article
C2 - 41429566
SN - 1079-5006
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
ER -