Objective: The objective of this cross-sectional study was to analyze the relationship between symptoms of central sensitization (CS) and important cognitive behavioral and psychosocial factors in a sample of patients with chronic nonspecific low back pain. Methods: Participants with chronic nonspecific low back pain for at least 3 months were included in the study. They completed several questionnaires and a functional test. Pearson's correlation was used to analyze associations between symptoms of CS and pain behavior, functioning, pain, pain catastrophizing, kinesiophobia, and illness perceptions. Additionally, a between-group analysis was performed to compare patients with and without clinically relevant symptoms of CS. Results: Data from 38 participants were analyzed. Significant associations were found between symptoms of CS and all other outcomes, especially current pain (r = 0.510, P =.001), mean pain during the past 7 days (r = 0.505, P =.001), and pain catastrophizing (r = 0.518, P =.001). Patients with clinically relevant symptoms of CS scored significantly worse on all outcomes compared with persons without relevant symptoms of CS, except on functioning (P =.128). Conclusions: Symptoms of CS were significantly associated with psychosocial and cognitive behavioral factors. Patients exhibiting a clinically relevant degree of symptoms of CS scored significantly worse on most outcomes, compared with the subgroup of the sample with fewer symptoms of CS.
|Number of pages||10|
|Journal||Journal of Manipulative and Physiological Therapeutics|
|State||Published - Feb 2018|
Bibliographical noteFunding Information:
Eva Huysmans and Lisa Goudman are PhD research fellows of the Agency for Innovation by Science and Technology (IWT)–Applied Biomedical Research Program (TBM), Belgium. Kelly Ickmans is a postdoctoral research fellow of the IWT–TBM, Belgium under IWT Project No. 150180. Jo Nijs is holder of the chair Exercise Immunology and Chronic Fatigue in Health and Disease, funded by the European College for Decongestive Lymphatic Therapy, The Netherlands. Maarten Moens is a clinical investigator and received the Lyrica Independent Investigator Research Award (LIIRA). He received consultancy or speaker honoraria from Medtronic and Pfizer.
The original randomized controlled trial was funded by Nervomatrix Ltd., 4a Hagavish st., Netanya, 4250704, Israel.
- Central Nervous System Sensitization
- Illness Behavior
- Low Back Pain
ASJC Scopus subject areas