Association Between Symptoms of Central Sensitization and Cognitive Behavioral Factors in People With Chronic Nonspecific Low Back Pain: A Cross-sectional Study

Eva Huysmans; Kelly Ickmans; Dries Van Dyck; Jo Nijs; Yori Gidron; Nathalie Roussel; Andrea Polli; Maarten Moens; Lisa Goudman; Margot De Kooning

doi:10.1016/j.jmpt.2017.08.007

Association Between Symptoms of Central Sensitization and Cognitive Behavioral Factors in People With Chronic Nonspecific Low Back Pain: A Cross-sectional Study

Eva Huysmans, Kelly Ickmans, Dries Van Dyck, Jo Nijs, Yori Gidron, Nathalie Roussel, Andrea Polli, Maarten Moens, Lisa Goudman, Margot De Kooning

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: The objective of this cross-sectional study was to analyze the relationship between symptoms of central sensitization (CS) and important cognitive behavioral and psychosocial factors in a sample of patients with chronic nonspecific low back pain. Methods: Participants with chronic nonspecific low back pain for at least 3 months were included in the study. They completed several questionnaires and a functional test. Pearson's correlation was used to analyze associations between symptoms of CS and pain behavior, functioning, pain, pain catastrophizing, kinesiophobia, and illness perceptions. Additionally, a between-group analysis was performed to compare patients with and without clinically relevant symptoms of CS. Results: Data from 38 participants were analyzed. Significant associations were found between symptoms of CS and all other outcomes, especially current pain (r = 0.510, P =.001), mean pain during the past 7 days (r = 0.505, P =.001), and pain catastrophizing (r = 0.518, P =.001). Patients with clinically relevant symptoms of CS scored significantly worse on all outcomes compared with persons without relevant symptoms of CS, except on functioning (P =.128). Conclusions: Symptoms of CS were significantly associated with psychosocial and cognitive behavioral factors. Patients exhibiting a clinically relevant degree of symptoms of CS scored significantly worse on most outcomes, compared with the subgroup of the sample with fewer symptoms of CS.

Original language	English
Pages (from-to)	92-101
Number of pages	10
Journal	Journal of Manipulative and Physiological Therapeutics
Volume	41
Issue number	2
DOIs	https://doi.org/10.1016/j.jmpt.2017.08.007
State	Published - Feb 2018
Externally published	Yes

Bibliographical note

Funding Information:
Eva Huysmans and Lisa Goudman are PhD research fellows of the Agency for Innovation by Science and Technology (IWT)–Applied Biomedical Research Program (TBM), Belgium. Kelly Ickmans is a postdoctoral research fellow of the IWT–TBM, Belgium under IWT Project No. 150180. Jo Nijs is holder of the chair Exercise Immunology and Chronic Fatigue in Health and Disease, funded by the European College for Decongestive Lymphatic Therapy, The Netherlands. Maarten Moens is a clinical investigator and received the Lyrica Independent Investigator Research Award (LIIRA). He received consultancy or speaker honoraria from Medtronic and Pfizer.

Funding Information:
The original randomized controlled trial was funded by Nervomatrix Ltd., 4a Hagavish st., Netanya, 4250704, Israel.

Publisher Copyright:
© 2017

Keywords

Catastrophizing
Central Nervous System Sensitization
Illness Behavior
Low Back Pain

ASJC Scopus subject areas

Chiropractic

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10.1016/j.jmpt.2017.08.007

Cite this

Huysmans, E., Ickmans, K., Van Dyck, D., Nijs, J., Gidron, Y., Roussel, N., Polli, A., Moens, M., Goudman, L., & De Kooning, M. (2018). Association Between Symptoms of Central Sensitization and Cognitive Behavioral Factors in People With Chronic Nonspecific Low Back Pain: A Cross-sectional Study. Journal of Manipulative and Physiological Therapeutics, 41(2), 92-101. https://doi.org/10.1016/j.jmpt.2017.08.007

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abstract = "Objective: The objective of this cross-sectional study was to analyze the relationship between symptoms of central sensitization (CS) and important cognitive behavioral and psychosocial factors in a sample of patients with chronic nonspecific low back pain. Methods: Participants with chronic nonspecific low back pain for at least 3 months were included in the study. They completed several questionnaires and a functional test. Pearson's correlation was used to analyze associations between symptoms of CS and pain behavior, functioning, pain, pain catastrophizing, kinesiophobia, and illness perceptions. Additionally, a between-group analysis was performed to compare patients with and without clinically relevant symptoms of CS. Results: Data from 38 participants were analyzed. Significant associations were found between symptoms of CS and all other outcomes, especially current pain (r = 0.510, P =.001), mean pain during the past 7 days (r = 0.505, P =.001), and pain catastrophizing (r = 0.518, P =.001). Patients with clinically relevant symptoms of CS scored significantly worse on all outcomes compared with persons without relevant symptoms of CS, except on functioning (P =.128). Conclusions: Symptoms of CS were significantly associated with psychosocial and cognitive behavioral factors. Patients exhibiting a clinically relevant degree of symptoms of CS scored significantly worse on most outcomes, compared with the subgroup of the sample with fewer symptoms of CS.",

keywords = "Catastrophizing, Central Nervous System Sensitization, Illness Behavior, Low Back Pain",

author = "Eva Huysmans and Kelly Ickmans and {Van Dyck}, Dries and Jo Nijs and Yori Gidron and Nathalie Roussel and Andrea Polli and Maarten Moens and Lisa Goudman and {De Kooning}, Margot",

note = "Funding Information: Eva Huysmans and Lisa Goudman are PhD research fellows of the Agency for Innovation by Science and Technology (IWT)–Applied Biomedical Research Program (TBM), Belgium. Kelly Ickmans is a postdoctoral research fellow of the IWT–TBM, Belgium under IWT Project No. 150180. Jo Nijs is holder of the chair Exercise Immunology and Chronic Fatigue in Health and Disease, funded by the European College for Decongestive Lymphatic Therapy, The Netherlands. Maarten Moens is a clinical investigator and received the Lyrica Independent Investigator Research Award (LIIRA). He received consultancy or speaker honoraria from Medtronic and Pfizer. Funding Information: The original randomized controlled trial was funded by Nervomatrix Ltd., 4a Hagavish st., Netanya, 4250704, Israel. Publisher Copyright: {\textcopyright} 2017",

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Huysmans, E, Ickmans, K, Van Dyck, D, Nijs, J, Gidron, Y, Roussel, N, Polli, A, Moens, M, Goudman, L & De Kooning, M 2018, 'Association Between Symptoms of Central Sensitization and Cognitive Behavioral Factors in People With Chronic Nonspecific Low Back Pain: A Cross-sectional Study', Journal of Manipulative and Physiological Therapeutics, vol. 41, no. 2, pp. 92-101. https://doi.org/10.1016/j.jmpt.2017.08.007

Association Between Symptoms of Central Sensitization and Cognitive Behavioral Factors in People With Chronic Nonspecific Low Back Pain : A Cross-sectional Study. / Huysmans, Eva; Ickmans, Kelly; Van Dyck, Dries et al.

In: Journal of Manipulative and Physiological Therapeutics, Vol. 41, No. 2, 02.2018, p. 92-101.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Association Between Symptoms of Central Sensitization and Cognitive Behavioral Factors in People With Chronic Nonspecific Low Back Pain

T2 - A Cross-sectional Study

AU - Huysmans, Eva

AU - Ickmans, Kelly

AU - Van Dyck, Dries

AU - Nijs, Jo

AU - Gidron, Yori

AU - Roussel, Nathalie

AU - Polli, Andrea

AU - Moens, Maarten

AU - Goudman, Lisa

AU - De Kooning, Margot

N1 - Funding Information: Eva Huysmans and Lisa Goudman are PhD research fellows of the Agency for Innovation by Science and Technology (IWT)–Applied Biomedical Research Program (TBM), Belgium. Kelly Ickmans is a postdoctoral research fellow of the IWT–TBM, Belgium under IWT Project No. 150180. Jo Nijs is holder of the chair Exercise Immunology and Chronic Fatigue in Health and Disease, funded by the European College for Decongestive Lymphatic Therapy, The Netherlands. Maarten Moens is a clinical investigator and received the Lyrica Independent Investigator Research Award (LIIRA). He received consultancy or speaker honoraria from Medtronic and Pfizer. Funding Information: The original randomized controlled trial was funded by Nervomatrix Ltd., 4a Hagavish st., Netanya, 4250704, Israel. Publisher Copyright: © 2017

PY - 2018/2

Y1 - 2018/2

N2 - Objective: The objective of this cross-sectional study was to analyze the relationship between symptoms of central sensitization (CS) and important cognitive behavioral and psychosocial factors in a sample of patients with chronic nonspecific low back pain. Methods: Participants with chronic nonspecific low back pain for at least 3 months were included in the study. They completed several questionnaires and a functional test. Pearson's correlation was used to analyze associations between symptoms of CS and pain behavior, functioning, pain, pain catastrophizing, kinesiophobia, and illness perceptions. Additionally, a between-group analysis was performed to compare patients with and without clinically relevant symptoms of CS. Results: Data from 38 participants were analyzed. Significant associations were found between symptoms of CS and all other outcomes, especially current pain (r = 0.510, P =.001), mean pain during the past 7 days (r = 0.505, P =.001), and pain catastrophizing (r = 0.518, P =.001). Patients with clinically relevant symptoms of CS scored significantly worse on all outcomes compared with persons without relevant symptoms of CS, except on functioning (P =.128). Conclusions: Symptoms of CS were significantly associated with psychosocial and cognitive behavioral factors. Patients exhibiting a clinically relevant degree of symptoms of CS scored significantly worse on most outcomes, compared with the subgroup of the sample with fewer symptoms of CS.

AB - Objective: The objective of this cross-sectional study was to analyze the relationship between symptoms of central sensitization (CS) and important cognitive behavioral and psychosocial factors in a sample of patients with chronic nonspecific low back pain. Methods: Participants with chronic nonspecific low back pain for at least 3 months were included in the study. They completed several questionnaires and a functional test. Pearson's correlation was used to analyze associations between symptoms of CS and pain behavior, functioning, pain, pain catastrophizing, kinesiophobia, and illness perceptions. Additionally, a between-group analysis was performed to compare patients with and without clinically relevant symptoms of CS. Results: Data from 38 participants were analyzed. Significant associations were found between symptoms of CS and all other outcomes, especially current pain (r = 0.510, P =.001), mean pain during the past 7 days (r = 0.505, P =.001), and pain catastrophizing (r = 0.518, P =.001). Patients with clinically relevant symptoms of CS scored significantly worse on all outcomes compared with persons without relevant symptoms of CS, except on functioning (P =.128). Conclusions: Symptoms of CS were significantly associated with psychosocial and cognitive behavioral factors. Patients exhibiting a clinically relevant degree of symptoms of CS scored significantly worse on most outcomes, compared with the subgroup of the sample with fewer symptoms of CS.

KW - Catastrophizing

KW - Central Nervous System Sensitization

KW - Illness Behavior

KW - Low Back Pain

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Association Between Symptoms of Central Sensitization and Cognitive Behavioral Factors in People With Chronic Nonspecific Low Back Pain: A Cross-sectional Study

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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