Association between Anti-Cd4 antibodies and a decline in Cd4+lymphocytes in human immunodeficiency virus type 1 seroconverters

Multicenter AIDS Cohort Study

doi:10.1093/infdis/171.2.312

Association between Anti-Cd4 antibodies and a decline in Cd4⁺lymphocytes in human immunodeficiency virus type 1 seroconverters

Multicenter AIDS Cohort Study

Research output: Contribution to journal › Article › peer-review

Abstract

Serum specimens (n = 161) from 31 persons before and after human immunodeficiency virus type 1 (HIV-1) seroconversion were tested for anti-CD4 antibodies, These antibodies were detected by both ELISA and Western blot in 55% (17/31) of subjects when HIV-1 seroconversion was detected and in 26% (8/31) from sera obtained 6-24 months earlier, A decrease in CD4⁺cell number was associated more with development of anti-CD4 antibodies or peak anti-CD4 antibody activity than with development of anti-HIV-1 antibodies. Quantitative DNA polymerase chain reaction assay of peripheral blood mononuclear cells from 7 seroconverters showed evidence of HIV-1 infection in 4 of 4 specimens obtained after HIV-1 seroconversion but was nonreactive for 12 of 12 specimens obtained before HIV-1 seroconversion, including 4 specimens positive for anti-CD4 antibodies by ELISA and Western blot. Therefore, anti-CD4 antibodies are frequently present in the sera of HIV-I-infected persons before and at the time HIV-1 seroconversion is detectable and are associated with a decline in CD4⁺cell counts, but they are not a marker for HIV-1 infection in seronegative persons.

Original language	English
Pages (from-to)	312-319
Number of pages	8
Journal	Journal of Infectious Diseases
Volume	171
Issue number	2
DOIs	https://doi.org/10.1093/infdis/171.2.312
State	Published - Feb 1995
Externally published	Yes

Bibliographical note

Funding Information:
Received 12 April 1994; revised I August 1994. Presented in part: 93rd general meeting ofthe American Society for Microbiology, Atlanta, May 1993 (abstract T-22). All samples were obtained through procedures approved by the Human Volunteers Research Committee at the University of Maryland or Johns Hopkins University. No author has a commercial or other association that might pose a conflict of interest for the material presented. Grant support: Infectious Diseases Society of America (Burroughs Wellcome Young Investigator Award in Virology to S.K.): National Institutes of Health (AI-32535 and RR-00722). Reprints or correspondence: Dr. Susan Keay, Research Service, VA Medical Center, Room 38-184,10 N. Greene St., Baltimore, MD 21201. • Members are listed after the text.

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1093/infdis/171.2.312

Cite this

@article{cd73ed7b1df84dd794e39a8f064e50d7,

title = "Association between Anti-Cd4 antibodies and a decline in Cd4+lymphocytes in human immunodeficiency virus type 1 seroconverters",

abstract = "Serum specimens (n = 161) from 31 persons before and after human immunodeficiency virus type 1 (HIV-1) seroconversion were tested for anti-CD4 antibodies, These antibodies were detected by both ELISA and Western blot in 55% (17/31) of subjects when HIV-1 seroconversion was detected and in 26% (8/31) from sera obtained 6-24 months earlier, A decrease in CD4+cell number was associated more with development of anti-CD4 antibodies or peak anti-CD4 antibody activity than with development of anti-HIV-1 antibodies. Quantitative DNA polymerase chain reaction assay of peripheral blood mononuclear cells from 7 seroconverters showed evidence of HIV-1 infection in 4 of 4 specimens obtained after HIV-1 seroconversion but was nonreactive for 12 of 12 specimens obtained before HIV-1 seroconversion, including 4 specimens positive for anti-CD4 antibodies by ELISA and Western blot. Therefore, anti-CD4 antibodies are frequently present in the sera of HIV-I-infected persons before and at the time HIV-1 seroconversion is detectable and are associated with a decline in CD4+cell counts, but they are not a marker for HIV-1 infection in seronegative persons.",

author = "{Multicenter AIDS Cohort Study} and Susan Keay and Wayne Wecksler and Wasserman, {Steven S.} and Joseph Margolick and Homayoon Farzadegan and Alfred Saah and Neil Graham and Alvaro Munoz and Vincent Carey and Donald Hoover and Lisa Jacobson and Sol Su and Noya Galai and Jill Kirby and John Phair and John Chmiel and K. Sheridan and Bruce Cohen and Steven Wolinsky and Roger Detels and Barbara Vischer and John Fahey and Janis Giorgi and Jan Dudley and Jeremy Taylor and Moon Lee and Charles Rinaldo and Monto Ho and Lawrence Kingsley and Phalguni Gupta and A. Winkelstein and Lewis Schrager and Sten Vermund and Richard Kaslow and {Van Raden}, Mark and Daniela Seminara",

note = "Funding Information: Received 12 April 1994; revised I August 1994. Presented in part: 93rd general meeting ofthe American Society for Microbiology, Atlanta, May 1993 (abstract T-22). All samples were obtained through procedures approved by the Human Volunteers Research Committee at the University of Maryland or Johns Hopkins University. No author has a commercial or other association that might pose a conflict of interest for the material presented. Grant support: Infectious Diseases Society of America (Burroughs Wellcome Young Investigator Award in Virology to S.K.): National Institutes of Health (AI-32535 and RR-00722). Reprints or correspondence: Dr. Susan Keay, Research Service, VA Medical Center, Room 38-184,10 N. Greene St., Baltimore, MD 21201. • Members are listed after the text.",

year = "1995",

month = feb,

doi = "10.1093/infdis/171.2.312",

language = "English",

volume = "171",

pages = "312--319",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "2",

}

TY - JOUR

T1 - Association between Anti-Cd4 antibodies and a decline in Cd4+lymphocytes in human immunodeficiency virus type 1 seroconverters

AU - Multicenter AIDS Cohort Study

AU - Keay, Susan

AU - Wecksler, Wayne

AU - Wasserman, Steven S.

AU - Margolick, Joseph

AU - Farzadegan, Homayoon

AU - Saah, Alfred

AU - Graham, Neil

AU - Munoz, Alvaro

AU - Carey, Vincent

AU - Hoover, Donald

AU - Jacobson, Lisa

AU - Su, Sol

AU - Galai, Noya

AU - Kirby, Jill

AU - Phair, John

AU - Chmiel, John

AU - Sheridan, K.

AU - Cohen, Bruce

AU - Wolinsky, Steven

AU - Detels, Roger

AU - Vischer, Barbara

AU - Fahey, John

AU - Giorgi, Janis

AU - Dudley, Jan

AU - Taylor, Jeremy

AU - Lee, Moon

AU - Rinaldo, Charles

AU - Ho, Monto

AU - Kingsley, Lawrence

AU - Gupta, Phalguni

AU - Winkelstein, A.

AU - Schrager, Lewis

AU - Vermund, Sten

AU - Kaslow, Richard

AU - Van Raden, Mark

AU - Seminara, Daniela

N1 - Funding Information: Received 12 April 1994; revised I August 1994. Presented in part: 93rd general meeting ofthe American Society for Microbiology, Atlanta, May 1993 (abstract T-22). All samples were obtained through procedures approved by the Human Volunteers Research Committee at the University of Maryland or Johns Hopkins University. No author has a commercial or other association that might pose a conflict of interest for the material presented. Grant support: Infectious Diseases Society of America (Burroughs Wellcome Young Investigator Award in Virology to S.K.): National Institutes of Health (AI-32535 and RR-00722). Reprints or correspondence: Dr. Susan Keay, Research Service, VA Medical Center, Room 38-184,10 N. Greene St., Baltimore, MD 21201. • Members are listed after the text.

PY - 1995/2

Y1 - 1995/2

N2 - Serum specimens (n = 161) from 31 persons before and after human immunodeficiency virus type 1 (HIV-1) seroconversion were tested for anti-CD4 antibodies, These antibodies were detected by both ELISA and Western blot in 55% (17/31) of subjects when HIV-1 seroconversion was detected and in 26% (8/31) from sera obtained 6-24 months earlier, A decrease in CD4+cell number was associated more with development of anti-CD4 antibodies or peak anti-CD4 antibody activity than with development of anti-HIV-1 antibodies. Quantitative DNA polymerase chain reaction assay of peripheral blood mononuclear cells from 7 seroconverters showed evidence of HIV-1 infection in 4 of 4 specimens obtained after HIV-1 seroconversion but was nonreactive for 12 of 12 specimens obtained before HIV-1 seroconversion, including 4 specimens positive for anti-CD4 antibodies by ELISA and Western blot. Therefore, anti-CD4 antibodies are frequently present in the sera of HIV-I-infected persons before and at the time HIV-1 seroconversion is detectable and are associated with a decline in CD4+cell counts, but they are not a marker for HIV-1 infection in seronegative persons.

AB - Serum specimens (n = 161) from 31 persons before and after human immunodeficiency virus type 1 (HIV-1) seroconversion were tested for anti-CD4 antibodies, These antibodies were detected by both ELISA and Western blot in 55% (17/31) of subjects when HIV-1 seroconversion was detected and in 26% (8/31) from sera obtained 6-24 months earlier, A decrease in CD4+cell number was associated more with development of anti-CD4 antibodies or peak anti-CD4 antibody activity than with development of anti-HIV-1 antibodies. Quantitative DNA polymerase chain reaction assay of peripheral blood mononuclear cells from 7 seroconverters showed evidence of HIV-1 infection in 4 of 4 specimens obtained after HIV-1 seroconversion but was nonreactive for 12 of 12 specimens obtained before HIV-1 seroconversion, including 4 specimens positive for anti-CD4 antibodies by ELISA and Western blot. Therefore, anti-CD4 antibodies are frequently present in the sera of HIV-I-infected persons before and at the time HIV-1 seroconversion is detectable and are associated with a decline in CD4+cell counts, but they are not a marker for HIV-1 infection in seronegative persons.

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