TY - JOUR
T1 - Association between ambient particulate matter and preterm birth stratified by temperature
T2 - A population-based pregnancy cohort study
AU - Ahmad, Wiessam Abu
AU - Nirel, Ronit
AU - Golan, Rachel
AU - Kloog, Itai
AU - Rotem, Ran
AU - Negev, Maya
AU - Koren, Gideon
AU - Levine, Hagai
N1 - Publisher Copyright:
© 2023 Elsevier GmbH
PY - 2023/9
Y1 - 2023/9
N2 - A growing body of literature reports associations between exposure to particulate matter with aerodynamic diameters ≤2.5 μm (PM2.5) and 2.5–10 μm (PM10-2.5) during pregnancy and preterm birth (PTB). However, the role of ambient temperature in PM-PTB associations was rarely investigated. In Israel, we used Maccabi Healthcare Services data to establish a population-based cohort of 381,265 singleton births reaching 24–42 weeks’ gestation and birth weight of 500–5000 g (2004–2015). Daily PM and ambient temperature predictions from a satellite-based spatiotemporal model, at a 1 × 1 km spatial resolution, were linked to the date of birth and maternal residence. Mixed effects Cox regression models, adjusted for covariates, with a random intercept at the mother level were used to assess associations between mean exposure during pregnancy and PTB. We found that exposure to PM2.5 was positively associated with PTB when the average exposure during pregnancy was either low (first quintile) or high (fifth quintile), compared to exposure in the 2nd-4th quintiles, with hazard ratios (HRs) 1.18 (95% confidence interval [CI], 1.13–1.24) and 1.07 (95% CI, 1.02–1.12), respectively. The results revealed effect modification of temperature. For mothers exposed to low (below median) average temperature during pregnancy, HRs of PTB were 0.93 (95% CI, 0.87–1.00) and 1.21 (95% CI, 1.14–1.29) for the first and fifth PM2.5 quintiles, respectively, when compared to the 2nd-4th quintiles. However, a reverse trend was indicated for high-temperature pregnancies, where the corresponding HRs were 1.48 (95% CI, 1.39–1.58) and 0.92, (95% CI, 0.96–0.98). In conclusion, consideration of climatic factors can provide new insights into the risk of PTB as a result of exposure to PM2.5 during pregnancy.
AB - A growing body of literature reports associations between exposure to particulate matter with aerodynamic diameters ≤2.5 μm (PM2.5) and 2.5–10 μm (PM10-2.5) during pregnancy and preterm birth (PTB). However, the role of ambient temperature in PM-PTB associations was rarely investigated. In Israel, we used Maccabi Healthcare Services data to establish a population-based cohort of 381,265 singleton births reaching 24–42 weeks’ gestation and birth weight of 500–5000 g (2004–2015). Daily PM and ambient temperature predictions from a satellite-based spatiotemporal model, at a 1 × 1 km spatial resolution, were linked to the date of birth and maternal residence. Mixed effects Cox regression models, adjusted for covariates, with a random intercept at the mother level were used to assess associations between mean exposure during pregnancy and PTB. We found that exposure to PM2.5 was positively associated with PTB when the average exposure during pregnancy was either low (first quintile) or high (fifth quintile), compared to exposure in the 2nd-4th quintiles, with hazard ratios (HRs) 1.18 (95% confidence interval [CI], 1.13–1.24) and 1.07 (95% CI, 1.02–1.12), respectively. The results revealed effect modification of temperature. For mothers exposed to low (below median) average temperature during pregnancy, HRs of PTB were 0.93 (95% CI, 0.87–1.00) and 1.21 (95% CI, 1.14–1.29) for the first and fifth PM2.5 quintiles, respectively, when compared to the 2nd-4th quintiles. However, a reverse trend was indicated for high-temperature pregnancies, where the corresponding HRs were 1.48 (95% CI, 1.39–1.58) and 0.92, (95% CI, 0.96–0.98). In conclusion, consideration of climatic factors can provide new insights into the risk of PTB as a result of exposure to PM2.5 during pregnancy.
KW - Adverse birth outcome
KW - Air pollution
KW - Ambient temperature
KW - Particulate matter
KW - Preterm birth
UR - http://www.scopus.com/inward/record.url?scp=85173537864&partnerID=8YFLogxK
U2 - 10.1016/j.ijheh.2023.114269
DO - 10.1016/j.ijheh.2023.114269
M3 - Article
C2 - 37832218
AN - SCOPUS:85173537864
SN - 1438-4639
VL - 254
JO - International Journal of Hygiene and Environmental Health
JF - International Journal of Hygiene and Environmental Health
M1 - 114269
ER -