ARTS, the unusual septin: Structural and functional aspects

Yael Mandel-Gutfreund, Idit Kosti, Sarit Larisch

Research output: Contribution to journalArticlepeer-review

Abstract

The human Septin 4 gene (Sept4) encodes two major protein isoforms; Sept4-i1 (H5/PNUTL2) and Sept4-i2/ARTS. Septins have been traditionally studied for their role in cytokinesis and their filament-forming abilities, but subsequently have been implicated in diverse functions, including membrane dynamics, cytoskeletal reorganization, vesicle trafficking, and tumorigenesis. ARTS is localized at mitochondria and promotes programmed cell death (apoptosis). These features distinguish ARTS from any other known human septin family member. This review compares the structural and functional properties of ARTS with other septins. In addition, it describes how a combination of two distinct promoters, differential splicing, and intron retention leads to the generation of two different Sept4 variants with diverse biological activity.

Original languageEnglish
Pages (from-to)783-790
Number of pages8
JournalBiological Chemistry
Volume392
Issue number8-9
DOIs
StatePublished - 1 Aug 2011

Bibliographical note

Funding Information:
We are very grateful to Hermann Steller for critical reading of the manuscript and to Juliana Kagan for technical assistance. Work from SL’s laboratory described in this review was supported by funds from US Israel Binational Science Foundation grant 2003085 (to SL), Israel Science Foundation grant 1264/06 (to SL), and a grant from Israel Cancer Association (to SL).

Keywords

  • ARTS
  • Sept4
  • XIAP
  • apoptosis
  • mitochondria
  • tumor suppressor protein

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry
  • Clinical Biochemistry

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