Articulating the “stem cell niche” paradigm through the lens of non-model aquatic invertebrates

P. Martinez; L. Ballarin; A. V. Ereskovsky; E. Gazave; B. Hobmayer; L. Manni; E. Rottinger; S. G. Sprecher; S. Tiozzo; A. Varela-Coelho; B. Rinkevich

doi:10.1186/s12915-022-01230-5

Articulating the “stem cell niche” paradigm through the lens of non-model aquatic invertebrates

P. Martinez, L. Ballarin, A. V. Ereskovsky, E. Gazave, B. Hobmayer, L. Manni, E. Rottinger, S. G. Sprecher, S. Tiozzo, A. Varela-Coelho, B. Rinkevich

Research output: Contribution to journal › Review article › peer-review

Abstract

Stem cells (SCs) in vertebrates typically reside in “stem cell niches” (SCNs), morphologically restricted tissue microenvironments that are important for SC survival and proliferation. SCNs are broadly defined by properties including physical location, but in contrast to vertebrates and other “model” organisms, aquatic invertebrate SCs do not have clearly documented niche outlines or properties. Life strategies such as regeneration or asexual reproduction may have conditioned the niche architectural variability in aquatic or marine animal groups. By both establishing the invertebrates SCNs as independent types, yet allowing inclusiveness among them, the comparative analysis will allow the future functional characterization of SCNs.

Original language	English
Article number	23
Journal	BMC Biology
Volume	20
Issue number	1
DOIs	https://doi.org/10.1186/s12915-022-01230-5
State	Published - 20 Jan 2022
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2022, The Author(s).

Keywords

Adult stem cell (ASCs)
Germline stem cells (GSCs)
Marine/aquatic organisms
Phyletic diversity
Self-renewal
Stem cell niche (SCN)

ASJC Scopus subject areas

Biotechnology
Structural Biology
Ecology, Evolution, Behavior and Systematics
Physiology
General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences
Plant Science
Developmental Biology
Cell Biology

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10.1186/s12915-022-01230-5

Cite this

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title = "Articulating the “stem cell niche” paradigm through the lens of non-model aquatic invertebrates",

abstract = "Stem cells (SCs) in vertebrates typically reside in “stem cell niches” (SCNs), morphologically restricted tissue microenvironments that are important for SC survival and proliferation. SCNs are broadly defined by properties including physical location, but in contrast to vertebrates and other “model” organisms, aquatic invertebrate SCs do not have clearly documented niche outlines or properties. Life strategies such as regeneration or asexual reproduction may have conditioned the niche architectural variability in aquatic or marine animal groups. By both establishing the invertebrates SCNs as independent types, yet allowing inclusiveness among them, the comparative analysis will allow the future functional characterization of SCNs.",

keywords = "Adult stem cell (ASCs), Germline stem cells (GSCs), Marine/aquatic organisms, Phyletic diversity, Self-renewal, Stem cell niche (SCN)",

author = "P. Martinez and L. Ballarin and Ereskovsky, {A. V.} and E. Gazave and B. Hobmayer and L. Manni and E. Rottinger and Sprecher, {S. G.} and S. Tiozzo and A. Varela-Coelho and B. Rinkevich",

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doi = "10.1186/s12915-022-01230-5",

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AU - Martinez, P.

AU - Ballarin, L.

AU - Ereskovsky, A. V.

AU - Gazave, E.

AU - Hobmayer, B.

AU - Manni, L.

AU - Rottinger, E.

AU - Sprecher, S. G.

AU - Tiozzo, S.

AU - Varela-Coelho, A.

AU - Rinkevich, B.

PY - 2022/1/20

Y1 - 2022/1/20

N2 - Stem cells (SCs) in vertebrates typically reside in “stem cell niches” (SCNs), morphologically restricted tissue microenvironments that are important for SC survival and proliferation. SCNs are broadly defined by properties including physical location, but in contrast to vertebrates and other “model” organisms, aquatic invertebrate SCs do not have clearly documented niche outlines or properties. Life strategies such as regeneration or asexual reproduction may have conditioned the niche architectural variability in aquatic or marine animal groups. By both establishing the invertebrates SCNs as independent types, yet allowing inclusiveness among them, the comparative analysis will allow the future functional characterization of SCNs.

AB - Stem cells (SCs) in vertebrates typically reside in “stem cell niches” (SCNs), morphologically restricted tissue microenvironments that are important for SC survival and proliferation. SCNs are broadly defined by properties including physical location, but in contrast to vertebrates and other “model” organisms, aquatic invertebrate SCs do not have clearly documented niche outlines or properties. Life strategies such as regeneration or asexual reproduction may have conditioned the niche architectural variability in aquatic or marine animal groups. By both establishing the invertebrates SCNs as independent types, yet allowing inclusiveness among them, the comparative analysis will allow the future functional characterization of SCNs.

KW - Adult stem cell (ASCs)

KW - Germline stem cells (GSCs)

KW - Marine/aquatic organisms

KW - Phyletic diversity

KW - Self-renewal

KW - Stem cell niche (SCN)

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U2 - 10.1186/s12915-022-01230-5

DO - 10.1186/s12915-022-01230-5

M3 - Review article

C2 - 35057814

AN - SCOPUS:85123280648

SN - 1741-7007

VL - 20

JO - BMC Biology

JF - BMC Biology

IS - 1

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ER -

Articulating the “stem cell niche” paradigm through the lens of non-model aquatic invertebrates

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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Cite this