Antigen-receptor degeneracy and immunological paradigms

Irun R. Cohen; Uri Hershberg; Sorin Solomon

doi:10.1016/j.molimm.2003.11.020

Antigen-receptor degeneracy and immunological paradigms

Irun R. Cohen, Uri Hershberg, Sorin Solomon

Research output: Contribution to journal › Article › peer-review

Abstract

This paper discusses some consequences of the discovery that antigen receptors are degenerate: Immune specificity, in contrast to the tenets of the clonal selection paradigm, must be generated by the immune response down-stream of initial antigen recognition; and specificity is a property of a collective of cells and not of single clones.

Original language	English
Pages (from-to)	993-996
Number of pages	4
Journal	Molecular Immunology
Volume	40
Issue number	14-15
DOIs	https://doi.org/10.1016/j.molimm.2003.11.020
State	Published - Feb 2004
Externally published	Yes

Bibliographical note

Funding Information:
I.R.C. is the incumbent of the Mauerberger Chair of Immunology at the Weizmann Institute of Science and the Director of the Center for the Study of Emerging Diseases, Jerusalem. U.H. is a recipient of the Levi Eshkol Fellowship. The research of S.S. is partly supported by the Israel Science Foundation.

Keywords

Clonal selection
Cognitive paradigm
Degeneracy
Inflammation
Specificity
T cells
T-cell receptor

ASJC Scopus subject areas

Immunology
Molecular Biology

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10.1016/j.molimm.2003.11.020

Cite this

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author = "Cohen, {Irun R.} and Uri Hershberg and Sorin Solomon",

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KW - Cognitive paradigm

KW - Degeneracy

KW - Inflammation

KW - Specificity

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KW - T-cell receptor

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ER -

Antigen-receptor degeneracy and immunological paradigms

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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