Anticancer potential of aloes: Antioxidant, antiproliferative, and immunostimulatory attributes

Eli Harlev, Eviatar Nevo, Ephraim P. Lansky, Rivka Ofir, Anupam Bishayee

Research output: Contribution to journalReview articlepeer-review

Abstract

Aloe is a genus of medicinal plants with a notable history of medical use. Basic research over the past couple of decades has begun to reveal the extent of Aloes pharmaceutical potential, particularly against neoplastic disease. This review looks at Aloe, both the genus and the folk medicine, often being called informally "aloeso", and delineates their chemistry and anticancer pharmacognosy. Structures of key compounds are provided, and their pharmacological activities reviewed. Particular attention is given to their free radical scavenging, antiproliferative, and immunostimulatory properties. This review highlights major research directions on aloes, reflecting the enormous potential of natural sources, and of the genus Aloe in particular, in preventing and treating cancer.

Original languageEnglish
Pages (from-to)843-852
Number of pages10
JournalPlanta Medica
Volume78
Issue number9
DOIs
StatePublished - 2012

Keywords

  • acemannan
  • Aloe vera
  • aloe-emodin
  • anticancer
  • antiproliferative
  • immunobiology
  • Xanthorrhoeaceae

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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