This research shows the phenolic composition and anti-inflammation properties of fruiting bodies and mycelia of 15 strains of 12 species of higher Basidiomycetes medicinal mushrooms. In this research, 15 extracts were prepared and their effects on inflammation-related mediators in RAW 264.7 cells were evaluated. In the extracts, amounts of total phenols ranged from 8.47 to 70.32 gallic acid equivalents mg/g and amounts of flavonoids ranged from 0.13 to 15.21 rutin equivalents mg/g. The production of nitric oxide, tumor necrosis factor-α, and interleukin-6 was decreased at different levels by these extracts, whereas the production of interleukin-10 was increased by 6 of the extracts. Overall, Cordyceps militaris fruiting bodies, Grifola frondosa fruiting bodies, and Ophiocordyceps sinensis mycelia might be used to ameliorate inflammatory responses.
|Number of pages||11|
|Journal||International Journal of Medicinal Mushrooms|
|State||Published - 2016|
Bibliographical noteFunding Information:
This study was supported by the Ministry of Science and Technology, Taiwan, Republic of China (MOST-104-2911-I-005-301, NSC-103-2911-I-005-301) and the Ministry of Education, Taiwan, R.O.C., under the ATU plan.
© 2016 Begell House, Inc.
- Fruiting body
- Medicinal mushrooms
ASJC Scopus subject areas
- Applied Microbiology and Biotechnology
- Drug Discovery