Anti-inflammation properties of fruiting bodies and submerged cultured mycelia of culinary-medicinal higher basidiomycetes mushrooms

Rao Chi Chien, Lan Min Lin, Yuan Hua Chang, Yu Chieh Lin, Pei Hsuan Wu, Mikheil D. Asatiani, Sophie Gabrielle Wasser, Maxim Krakhmalnyi, Abed Agbarya, Solomon P. Wasser, Jeng Leun Mau

Research output: Contribution to journalArticlepeer-review

Abstract

This research shows the phenolic composition and anti-inflammation properties of fruiting bodies and mycelia of 15 strains of 12 species of higher Basidiomycetes medicinal mushrooms. In this research, 15 extracts were prepared and their effects on inflammation-related mediators in RAW 264.7 cells were evaluated. In the extracts, amounts of total phenols ranged from 8.47 to 70.32 gallic acid equivalents mg/g and amounts of flavonoids ranged from 0.13 to 15.21 rutin equivalents mg/g. The production of nitric oxide, tumor necrosis factor-α, and interleukin-6 was decreased at different levels by these extracts, whereas the production of interleukin-10 was increased by 6 of the extracts. Overall, Cordyceps militaris fruiting bodies, Grifola frondosa fruiting bodies, and Ophiocordyceps sinensis mycelia might be used to ameliorate inflammatory responses.

Original languageEnglish
Pages (from-to)999-1009
Number of pages11
JournalInternational Journal of Medicinal Mushrooms
Volume18
Issue number11
DOIs
StatePublished - 2016

Bibliographical note

Funding Information:
This study was supported by the Ministry of Science and Technology, Taiwan, Republic of China (MOST-104-2911-I-005-301, NSC-103-2911-I-005-301) and the Ministry of Education, Taiwan, R.O.C., under the ATU plan.

Publisher Copyright:
© 2016 Begell House, Inc.

Keywords

  • Flavonoids
  • Fruiting body
  • Inflammation
  • Medicinal mushrooms
  • Mycelium
  • Phenols

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Pharmacology
  • Drug Discovery

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