Abstract
ARTS (Sept4_i2) is a pro-apoptotic mitochondrial tumor suppressor protein which binds to and causes degradation of XIAP (X-linked inhibitor of apoptosis). We recently showed that ARTS brings XIAP into close proximity to Bcl-2, creating a complex which enables degradation of both these major anti-apoptotic proteins and promotes apoptosis. The possible therapeutic implications are discussed here.
| Original language | English |
|---|---|
| Article number | e1441630 |
| Journal | Molecular and Cellular Oncology |
| Volume | 5 |
| Issue number | 4 |
| DOIs | |
| State | Published - 4 Jul 2018 |
Bibliographical note
Publisher Copyright:© 2018, © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Keywords
- Apoptosis
- Bcl-2, XIAP
- Caspases
- E3-ligase
- Mitochondria
- Protein degradation
- Ubiquitin
ASJC Scopus subject areas
- Molecular Medicine
- Cancer Research
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