Another one bites the dust; ARTS enables degradation of Bcl-2 by XIAP

Dana Mamriev; Sarit Larisch

doi:10.1080/23723556.2018.1441630

Another one bites the dust; ARTS enables degradation of Bcl-2 by XIAP

Research output: Contribution to journal › Article › peer-review

Abstract

ARTS (Sept4_i2) is a pro-apoptotic mitochondrial tumor suppressor protein which binds to and causes degradation of XIAP (X-linked inhibitor of apoptosis). We recently showed that ARTS brings XIAP into close proximity to Bcl-2, creating a complex which enables degradation of both these major anti-apoptotic proteins and promotes apoptosis. The possible therapeutic implications are discussed here.

Original language	English
Article number	e1441630
Journal	Molecular and Cellular Oncology
Volume	5
Issue number	4
DOIs	https://doi.org/10.1080/23723556.2018.1441630
State	Published - 4 Jul 2018

Bibliographical note

Publisher Copyright:
© 2018, © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

Keywords

Apoptosis
Bcl-2, XIAP
Caspases
E3-ligase
Mitochondria
Protein degradation
Ubiquitin

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

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10.1080/23723556.2018.1441630

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abstract = "ARTS (Sept4_i2) is a pro-apoptotic mitochondrial tumor suppressor protein which binds to and causes degradation of XIAP (X-linked inhibitor of apoptosis). We recently showed that ARTS brings XIAP into close proximity to Bcl-2, creating a complex which enables degradation of both these major anti-apoptotic proteins and promotes apoptosis. The possible therapeutic implications are discussed here.",

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AU - Larisch, Sarit

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AB - ARTS (Sept4_i2) is a pro-apoptotic mitochondrial tumor suppressor protein which binds to and causes degradation of XIAP (X-linked inhibitor of apoptosis). We recently showed that ARTS brings XIAP into close proximity to Bcl-2, creating a complex which enables degradation of both these major anti-apoptotic proteins and promotes apoptosis. The possible therapeutic implications are discussed here.

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KW - Bcl-2, XIAP

KW - Caspases

KW - E3-ligase

KW - Mitochondria

KW - Protein degradation

KW - Ubiquitin

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Another one bites the dust; ARTS enables degradation of Bcl-2 by XIAP

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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