Another one bites the dust; ARTS enables degradation of Bcl-2 by XIAP

Dana Mamriev, Sarit Larisch

Research output: Contribution to journalArticlepeer-review


ARTS (Sept4_i2) is a pro-apoptotic mitochondrial tumor suppressor protein which binds to and causes degradation of XIAP (X-linked inhibitor of apoptosis). We recently showed that ARTS brings XIAP into close proximity to Bcl-2, creating a complex which enables degradation of both these major anti-apoptotic proteins and promotes apoptosis. The possible therapeutic implications are discussed here.

Original languageEnglish
Article numbere1441630
JournalMolecular and Cellular Oncology
Issue number4
StatePublished - 4 Jul 2018

Bibliographical note

Publisher Copyright:
© 2018, © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.


  • Apoptosis
  • Bcl-2, XIAP
  • Caspases
  • E3-ligase
  • Mitochondria
  • Protein degradation
  • Ubiquitin

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research


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