An animal model of chemotherapy-induced vagal neuropathy

Irit Weissman-Fogel, Arkadi Dashkovsky, Zeev Rogowski, David Yarnitsky

Research output: Contribution to journalArticlepeer-review


In this study we establish an animal model of chemotherapy-induced autonomic neuropathy. Rats were injected with vincristine (30 and 100 μg/kg/day) for 2 weeks while cardiovascular parameters were collected telemetrically. Vincristine caused a dose-dependent decrease in vagal activity expressed by decreased parasympathetic parameters of heart rate variability, without expression of damage to the cardiac sympathetic innervation. This model can serve in assessing the potential contribution of chemotherapy-induced vagal neuropathy to morbidity and mortality.

Original languageEnglish
Pages (from-to)1634-1637
Number of pages4
JournalMuscle and Nerve
Issue number6
StatePublished - Dec 2008


  • Animal model
  • Heart rate variability
  • Vagal neuropathy
  • Vincristine

ASJC Scopus subject areas

  • Clinical Neurology
  • Physiology (medical)
  • Cellular and Molecular Neuroscience
  • Physiology


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