An animal model of chemotherapy-induced vagal neuropathy

Irit Weissman-Fogel; Arkadi Dashkovsky; Zeev Rogowski; David Yarnitsky

doi:10.1002/mus.21152

An animal model of chemotherapy-induced vagal neuropathy

Irit Weissman-Fogel, Arkadi Dashkovsky, Zeev Rogowski, David Yarnitsky

Department of Physical Therapy

Research output: Contribution to journal › Article › peer-review

Abstract

In this study we establish an animal model of chemotherapy-induced autonomic neuropathy. Rats were injected with vincristine (30 and 100 μg/kg/day) for 2 weeks while cardiovascular parameters were collected telemetrically. Vincristine caused a dose-dependent decrease in vagal activity expressed by decreased parasympathetic parameters of heart rate variability, without expression of damage to the cardiac sympathetic innervation. This model can serve in assessing the potential contribution of chemotherapy-induced vagal neuropathy to morbidity and mortality.

Original language	English
Pages (from-to)	1634-1637
Number of pages	4
Journal	Muscle and Nerve
Volume	38
Issue number	6
DOIs	https://doi.org/10.1002/mus.21152
State	Published - Dec 2008

Keywords

Animal model
Heart rate variability
Vagal neuropathy
Vincristine

ASJC Scopus subject areas

Physiology
Clinical Neurology
Cellular and Molecular Neuroscience
Physiology (medical)

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10.1002/mus.21152

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An animal model of chemotherapy-induced vagal neuropathy

Abstract

Keywords

ASJC Scopus subject areas

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