An α2 antagonist, idazoxan, enhances EPSP-spike coupling in the rat dentate gyrus

Gal Richter-Levin; Menahem Segal; Susan Sara

doi:10.1016/0006-8993(91)90521-V

An α₂ antagonist, idazoxan, enhances EPSP-spike coupling in the rat dentate gyrus

Gal Richter-Levin
, Menahem Segal
, Susan Sara

Research output: Contribution to journal › Article › peer-review

Abstract

the effect of the α₂ antagonist, idazoxan (IDA), on the excitability of neurons in the dentate gyrus of the hippocampus was studied. Population field potentials (PS) evoked by stimulation of the perforant pathway were measured before and after drug treatment. IDA enhanced the amplitude of the PS, while decreasing the slope of the EPSP. Neurotaxic destruction of noradrenergic nerve terminals completely abolished the IDA effect, arguing that its mechanism of action is through enhanced release of noradrenaline (NA). It is proposed that NA enhances the EPSP-to-spike coupling component of the PS.

Original language	English
Pages (from-to)	291-294
Number of pages	4
Journal	Brain Research
Volume	540
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(91)90521-V
State	Published - 1 Feb 1991
Externally published	Yes

Keywords

Dentate gyrus
Evoked potential
Hippocampus
Idazoxan
Noradreline
α Receptor

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/0006-8993(91)90521-V

Cite this

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title = "An α2 antagonist, idazoxan, enhances EPSP-spike coupling in the rat dentate gyrus",

abstract = "the effect of the α2 antagonist, idazoxan (IDA), on the excitability of neurons in the dentate gyrus of the hippocampus was studied. Population field potentials (PS) evoked by stimulation of the perforant pathway were measured before and after drug treatment. IDA enhanced the amplitude of the PS, while decreasing the slope of the EPSP. Neurotaxic destruction of noradrenergic nerve terminals completely abolished the IDA effect, arguing that its mechanism of action is through enhanced release of noradrenaline (NA). It is proposed that NA enhances the EPSP-to-spike coupling component of the PS.",

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KW - Dentate gyrus

KW - Evoked potential

KW - Hippocampus

KW - Idazoxan

KW - Noradreline

KW - α Receptor

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