Alzheimer's disease (AD) is the leading neurodegenerative disease worldwide and the expected rise in patient numbers is a critical threat to our health care systems. Current treatment strategies are of limited efficacy and only transiently active. Thus, there is an urgent need for a better understanding of the pathomechanisms involved, the precise sequence of events, and potential drug targets. Current research strategies are based on studies on animal models of the disease and mostly focus on interference with the key pathological hallmarks, beta-amyloid peptide accumulation and deposition and the neurofibrillary tangle formation. Further efforts need to be invested to complement our knowledge about AD and to identify new times and sites of therapeutic intervention.
|Title of host publication||Cognitive Enhancement|
|Subtitle of host publication||Pharmacologic, Environmental and Genetic Factors|
|Number of pages||39|
|State||Published - 8 Jan 2015|
Bibliographical notePublisher Copyright:
© 2015 Elsevier Inc. All rights reserved.
- Amyloid precursor protein
- Cognitive impairment
- Transgenic mice
ASJC Scopus subject areas
- Medicine (all)