Altered Volatile Organic Compound Profile in Transgenic Rats Bearing A53T Mutation of Human α-Synuclein: Comparison with Dopaminergic and Serotonergic Denervation

John P.M. Finberg, Yuval Aluf, Yelena Loboda, Morad K. Nakhleh, Raneen Jeries, Manal Abud-Hawa, Salman Zubedat, Avi Avital, Soliman Khatib, Jacob Vaya, Hossam Haick

Research output: Contribution to journalArticlepeer-review

Abstract

Early diagnosis of Parkinson's disease (PD) is of great importance due its progressive phenotype. Neuroprotective drugs could potentially slow down disease progression if used at early stages. Previously, we have reported an altered content of volatile organic compounds (VOCs) in the breath of rats following a 50% reduction in striatal dopamine (DA) content induced by 6-hydroxydopamine. We now report on the difference in the breath-print and content of VOCs between rats with mild and severe lesions of DA neurons, serotonergic neuronal lesions, and transgenic (Tg) rats carrying the PD-producing A53T mutation of the SNCA (α-synuclein) gene. The Tg rats had an increased content of 3-octen-1-ol and 4-chloro-3-methyl phenol in blood, while in brain tissue, hexanal, hexanol, and 2,3-octanedione were present in controls but absent in Tg rats. Levels of 1-heptyl-2-methyl cyclopropane were increased in brain tissue of Tg rats. The data confirm the potential of breath analysis for detection of human idiosyncratic as well as autosomal dominant PD.

Original languageEnglish
Pages (from-to)291-297
Number of pages7
JournalACS Chemical Neuroscience
Volume9
Issue number2
DOIs
StatePublished - 21 Feb 2018
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2017 American Chemical Society.

Keywords

  • 5,7-dihydroxytryptamine
  • 6-hydroxydopamine
  • Parkinson
  • breath
  • diagnosis
  • sensor
  • transgenic
  • volatile organic compound

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Biochemistry
  • Physiology
  • Cell Biology

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