Early diagnosis of Parkinson's disease (PD) is of great importance due its progressive phenotype. Neuroprotective drugs could potentially slow down disease progression if used at early stages. Previously, we have reported an altered content of volatile organic compounds (VOCs) in the breath of rats following a 50% reduction in striatal dopamine (DA) content induced by 6-hydroxydopamine. We now report on the difference in the breath-print and content of VOCs between rats with mild and severe lesions of DA neurons, serotonergic neuronal lesions, and transgenic (Tg) rats carrying the PD-producing A53T mutation of the SNCA (α-synuclein) gene. The Tg rats had an increased content of 3-octen-1-ol and 4-chloro-3-methyl phenol in blood, while in brain tissue, hexanal, hexanol, and 2,3-octanedione were present in controls but absent in Tg rats. Levels of 1-heptyl-2-methyl cyclopropane were increased in brain tissue of Tg rats. The data confirm the potential of breath analysis for detection of human idiosyncratic as well as autosomal dominant PD.
Bibliographical noteFunding Information:
*J. P. M. Finberg. E-mail: firstname.lastname@example.org. *H. Haick. E-mail: email@example.com. ORCID Hossam Haick: 0000-0002-2370-4073 Author Contributions Y.A., Y.L., U.T., M.K.N., R.J., M.A., S.Z. A.A., and S.K. contributed to acquisition of preclinical samples, breath and blood sample analysis, data interpretation, and revision and approval of the manuscript for important intellectual content. J.P.M.F., J.V., and H.H contributed to study design and supervision, interpretation of data, and manuscript writing and revision. Funding This research was funded from the Britain Israel Research and Academic Exchange Partnership (BIRAX; 62BX14RBHH), and Chief Scientist’s Office, Ministry of Industry, Trade and Labor, Government of Israel. Notes The authors declare no competing financial interest.
© 2017 American Chemical Society.
- volatile organic compound
ASJC Scopus subject areas
- Cognitive Neuroscience
- Cell Biology