TY - JOUR
T1 - Age of onset in obsessive-compulsive disorder
T2 - Admixture analysis with a large sample
AU - Anholt, G. E.
AU - Aderka, I. M.
AU - Van Balkom, A. J.L.M.
AU - Smit, J. H.
AU - Schruers, K.
AU - Van Der Wee, N. J.A.
AU - Eikelenboom, M.
AU - De Luca, V.
AU - Van Oppen, P.
PY - 2014/1
Y1 - 2014/1
N2 - Background Research into age of onset in obsessive-compulsive disorder (OCD) has indicated significant differences between patients with early and late onset of the disorder. However, multiple criteria have been used arbitrarily for differentiating between early-and late-onset OCD, rendering inconsistent results that are difficult to interpret. Method In the current study, admixture analysis was conducted in a sample of 377 OC patients to determine the number of underlying populations of age of onset and associated demographic and clinical characteristics. Various measures of anxiety, depression, co-morbidity, autism, OCD, tics and attention deficit hyperactivity disorder (ADHD) symptoms were administered. Results A bimodal age of onset was established and the best-fitting cut-off score between early and late age of onset was 20 years (early age of onset â
AB - Background Research into age of onset in obsessive-compulsive disorder (OCD) has indicated significant differences between patients with early and late onset of the disorder. However, multiple criteria have been used arbitrarily for differentiating between early-and late-onset OCD, rendering inconsistent results that are difficult to interpret. Method In the current study, admixture analysis was conducted in a sample of 377 OC patients to determine the number of underlying populations of age of onset and associated demographic and clinical characteristics. Various measures of anxiety, depression, co-morbidity, autism, OCD, tics and attention deficit hyperactivity disorder (ADHD) symptoms were administered. Results A bimodal age of onset was established and the best-fitting cut-off score between early and late age of onset was 20 years (early age of onset â
KW - Admixture analysis
KW - age of onset
KW - obsessive-compulsive disorder
UR - http://www.scopus.com/inward/record.url?scp=84889770716&partnerID=8YFLogxK
U2 - 10.1017/S0033291713000470
DO - 10.1017/S0033291713000470
M3 - Article
C2 - 23517651
AN - SCOPUS:84889770716
SN - 0033-2917
VL - 44
SP - 185
EP - 194
JO - Psychological Medicine
JF - Psychological Medicine
IS - 1
ER -