Adverse effects of mycelia and culture broth extracts from Bjerkandera adusta (Willd.: Fr.) P. Karst. and Hypholoma fasciculare (Huds.: Fr.) P. Kumm. on breast and prostate cancer cells

Ben Zion Zaidman; Anna Lutin; Solomon P. Wasser; Eviatar Nevo; Jamal A. Mahajna

doi:10.1615/IntJMedMushr.v9.i1.50

Adverse effects of mycelia and culture broth extracts from Bjerkandera adusta (Willd.: Fr.) P. Karst. and Hypholoma fasciculare (Huds.: Fr.) P. Kumm. on breast and prostate cancer cells

Ben Zion Zaidman, Anna Lutin, Solomon P. Wasser, Eviatar Nevo, Jamal A. Mahajna

Department of Evolutionary and Environmental Biology

Research output: Contribution to journal › Article › peer-review

Abstract

Bjerkandera adusta (Willd.: Fr.) P. Karst. (Hapalopilaceae) and Hypholoma fasciculare (Huds.: Fr.) P. Kumm. (Strophariaceae) higher Basidiomycetes are known for their exceptionally high concentrations of adsorbable organic halogens. The objective of this study was to test the effect of these secondary metabolites on breast and prostate cancer cells. We report that ethyl acetate mycelia and culture broth extracts from B. adusta and H. fasciculare inhibit breast cancer MDA-kb2 and MCF-7 cells and prostate cancer PC-3, DU 145, and LNCaP cell viability. Furthermore, H. fasciculare culture broth extract decreases both MDA-kb2, MCF-7, PC-3, DU 145, and LNCaP cell proliferation and transcriptional activity of the androgen receptor in dihydrotestosteron-induced MDA-kb2 cells.

Original language	English
Pages (from-to)	39-46
Number of pages	8
Journal	International Journal of Medicinal Mushrooms
Volume	9
Issue number	1
DOIs	https://doi.org/10.1615/IntJMedMushr.v9.i1.50
State	Published - 2007

Keywords

Androgen receptor
Bjerkandera adusta
Breast cancer
Hypholoma fasciculare
Liquid culture mycelia
Prostate cancer

ASJC Scopus subject areas

Applied Microbiology and Biotechnology
Pharmacology
Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1615/IntJMedMushr.v9.i1.50

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title = "Adverse effects of mycelia and culture broth extracts from Bjerkandera adusta (Willd.: Fr.) P. Karst. and Hypholoma fasciculare (Huds.: Fr.) P. Kumm. on breast and prostate cancer cells",

abstract = "Bjerkandera adusta (Willd.: Fr.) P. Karst. (Hapalopilaceae) and Hypholoma fasciculare (Huds.: Fr.) P. Kumm. (Strophariaceae) higher Basidiomycetes are known for their exceptionally high concentrations of adsorbable organic halogens. The objective of this study was to test the effect of these secondary metabolites on breast and prostate cancer cells. We report that ethyl acetate mycelia and culture broth extracts from B. adusta and H. fasciculare inhibit breast cancer MDA-kb2 and MCF-7 cells and prostate cancer PC-3, DU 145, and LNCaP cell viability. Furthermore, H. fasciculare culture broth extract decreases both MDA-kb2, MCF-7, PC-3, DU 145, and LNCaP cell proliferation and transcriptional activity of the androgen receptor in dihydrotestosteron-induced MDA-kb2 cells.",

keywords = "Androgen receptor, Bjerkandera adusta, Breast cancer, Hypholoma fasciculare, Liquid culture mycelia, Prostate cancer",

author = "Zaidman, {Ben Zion} and Anna Lutin and Wasser, {Solomon P.} and Eviatar Nevo and Mahajna, {Jamal A.}",

year = "2007",

doi = "10.1615/IntJMedMushr.v9.i1.50",

language = "English",

volume = "9",

pages = "39--46",

journal = "International Journal of Medicinal Mushrooms",

issn = "1521-9437",

publisher = "Begell House Inc.",

number = "1",

}

Adverse effects of mycelia and culture broth extracts from Bjerkandera adusta (Willd.: Fr.) P. Karst. and Hypholoma fasciculare (Huds.: Fr.) P. Kumm. on breast and prostate cancer cells. / Zaidman, Ben Zion; Lutin, Anna; Wasser, Solomon P. et al.
In: International Journal of Medicinal Mushrooms, Vol. 9, No. 1, 2007, p. 39-46.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Adverse effects of mycelia and culture broth extracts from Bjerkandera adusta (Willd.: Fr.) P. Karst. and Hypholoma fasciculare (Huds.: Fr.) P. Kumm. on breast and prostate cancer cells

AU - Zaidman, Ben Zion

AU - Lutin, Anna

AU - Wasser, Solomon P.

AU - Nevo, Eviatar

AU - Mahajna, Jamal A.

PY - 2007

Y1 - 2007

N2 - Bjerkandera adusta (Willd.: Fr.) P. Karst. (Hapalopilaceae) and Hypholoma fasciculare (Huds.: Fr.) P. Kumm. (Strophariaceae) higher Basidiomycetes are known for their exceptionally high concentrations of adsorbable organic halogens. The objective of this study was to test the effect of these secondary metabolites on breast and prostate cancer cells. We report that ethyl acetate mycelia and culture broth extracts from B. adusta and H. fasciculare inhibit breast cancer MDA-kb2 and MCF-7 cells and prostate cancer PC-3, DU 145, and LNCaP cell viability. Furthermore, H. fasciculare culture broth extract decreases both MDA-kb2, MCF-7, PC-3, DU 145, and LNCaP cell proliferation and transcriptional activity of the androgen receptor in dihydrotestosteron-induced MDA-kb2 cells.

AB - Bjerkandera adusta (Willd.: Fr.) P. Karst. (Hapalopilaceae) and Hypholoma fasciculare (Huds.: Fr.) P. Kumm. (Strophariaceae) higher Basidiomycetes are known for their exceptionally high concentrations of adsorbable organic halogens. The objective of this study was to test the effect of these secondary metabolites on breast and prostate cancer cells. We report that ethyl acetate mycelia and culture broth extracts from B. adusta and H. fasciculare inhibit breast cancer MDA-kb2 and MCF-7 cells and prostate cancer PC-3, DU 145, and LNCaP cell viability. Furthermore, H. fasciculare culture broth extract decreases both MDA-kb2, MCF-7, PC-3, DU 145, and LNCaP cell proliferation and transcriptional activity of the androgen receptor in dihydrotestosteron-induced MDA-kb2 cells.

KW - Androgen receptor

KW - Bjerkandera adusta

KW - Breast cancer

KW - Hypholoma fasciculare

KW - Liquid culture mycelia

KW - Prostate cancer

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DO - 10.1615/IntJMedMushr.v9.i1.50

M3 - Article

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SN - 1521-9437

VL - 9

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JO - International Journal of Medicinal Mushrooms

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Adverse effects of mycelia and culture broth extracts from Bjerkandera adusta (Willd.: Fr.) P. Karst. and Hypholoma fasciculare (Huds.: Fr.) P. Kumm. on breast and prostate cancer cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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