Adiponectin levels and genotype: A potential regulator of life span in humans

Gil Atzmon; Toni I. Pollin; Jill Crandall; Keith Tanner; Clyde B. Schechter; Philipp E. Scherer; Marielisa Rincon; Glenn Siegel; Micol Katz; Richard B. Lipton; Alan R. Shuldiner; Nir Barzilai

doi:10.1093/gerona/63.5.447

Adiponectin levels and genotype: A potential regulator of life span in humans

Gil Atzmon, Toni I. Pollin, Jill Crandall, Keith Tanner, Clyde B. Schechter, Philipp E. Scherer, Marielisa Rincon, Glenn Siegel, Micol Katz, Richard B. Lipton, Alan R. Shuldiner, Nir Barzilai

Research output: Contribution to journal › Article › peer-review

Abstract

Although caloric restriction in numerous models extends life, longevity in humans is suggested to be limited by the increased prevalence of obesity. Adiponectin, a fat-derived peptide, has a protective role against age-related disease, and thus is an excellent candidate gene for longevity. We studied adiponectin levels in centenarians (n = 118), their offspring (n = 228), and unrelated participants <95 (n = 78). Adiponectin levels were significantly greater in participants older than 95 years (p = .01), an effect that was independent of sex and body mass index (BMI). Adiponectin levels in the offspring were higher (following adjustment for age, sex, and BMI) compared to controls (p = .02), suggesting that inherited factors play a role in determining adiponectin levels. Over-representation of two common variants in Adiponectin gene (ADIPOQ) in male long-lived individuals combined with their independent association with elevated plasma adiponectin levels (in men and women) suggests that their presence may promote increased life span through the regulation of adiponectin production and/or secretion.

Original language	English
Pages (from-to)	447-453
Number of pages	7
Journal	Journals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume	63
Issue number	5
DOIs	https://doi.org/10.1093/gerona/63.5.447
State	Published - May 2008
Externally published	Yes

Bibliographical note

Funding Information:
ACKNOWLEDGMENTS This study was funded from grants by the Academy of Finland, the Ministry of Education, Finland, and the GENOMEUTWIN project (EU grant QLG2-CT-2002-01254).

Keywords

Adiponectin
Cardiovascular disease
Genetics
Longevity
Metabolic syndrome

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1093/gerona/63.5.447

Cite this

Atzmon, G., Pollin, T. I., Crandall, J., Tanner, K., Schechter, C. B., Scherer, P. E., Rincon, M., Siegel, G., Katz, M., Lipton, R. B., Shuldiner, A. R., & Barzilai, N. (2008). Adiponectin levels and genotype: A potential regulator of life span in humans. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 63(5), 447-453. https://doi.org/10.1093/gerona/63.5.447

@article{6cf04304eb884da5a2ceb4b51740643c,

title = "Adiponectin levels and genotype: A potential regulator of life span in humans",

abstract = "Although caloric restriction in numerous models extends life, longevity in humans is suggested to be limited by the increased prevalence of obesity. Adiponectin, a fat-derived peptide, has a protective role against age-related disease, and thus is an excellent candidate gene for longevity. We studied adiponectin levels in centenarians (n = 118), their offspring (n = 228), and unrelated participants <95 (n = 78). Adiponectin levels were significantly greater in participants older than 95 years (p = .01), an effect that was independent of sex and body mass index (BMI). Adiponectin levels in the offspring were higher (following adjustment for age, sex, and BMI) compared to controls (p = .02), suggesting that inherited factors play a role in determining adiponectin levels. Over-representation of two common variants in Adiponectin gene (ADIPOQ) in male long-lived individuals combined with their independent association with elevated plasma adiponectin levels (in men and women) suggests that their presence may promote increased life span through the regulation of adiponectin production and/or secretion.",

keywords = "Adiponectin, Cardiovascular disease, Genetics, Longevity, Metabolic syndrome",

author = "Gil Atzmon and Pollin, {Toni I.} and Jill Crandall and Keith Tanner and Schechter, {Clyde B.} and Scherer, {Philipp E.} and Marielisa Rincon and Glenn Siegel and Micol Katz and Lipton, {Richard B.} and Shuldiner, {Alan R.} and Nir Barzilai",

note = "Funding Information: ACKNOWLEDGMENTS This study was funded from grants by the Academy of Finland, the Ministry of Education, Finland, and the GENOMEUTWIN project (EU grant QLG2-CT-2002-01254).",

year = "2008",

month = may,

doi = "10.1093/gerona/63.5.447",

language = "English",

volume = "63",

pages = "447--453",

journal = "Journals of Gerontology - Series A Biological Sciences and Medical Sciences",

issn = "1079-5006",

publisher = "Oxford University Press",

number = "5",

}

Atzmon, G, Pollin, TI, Crandall, J, Tanner, K, Schechter, CB, Scherer, PE, Rincon, M, Siegel, G, Katz, M, Lipton, RB, Shuldiner, AR & Barzilai, N 2008, 'Adiponectin levels and genotype: A potential regulator of life span in humans', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 63, no. 5, pp. 447-453. https://doi.org/10.1093/gerona/63.5.447

TY - JOUR

T1 - Adiponectin levels and genotype

T2 - A potential regulator of life span in humans

AU - Atzmon, Gil

AU - Pollin, Toni I.

AU - Crandall, Jill

AU - Tanner, Keith

AU - Schechter, Clyde B.

AU - Scherer, Philipp E.

AU - Rincon, Marielisa

AU - Siegel, Glenn

AU - Katz, Micol

AU - Lipton, Richard B.

AU - Shuldiner, Alan R.

AU - Barzilai, Nir

N1 - Funding Information: ACKNOWLEDGMENTS This study was funded from grants by the Academy of Finland, the Ministry of Education, Finland, and the GENOMEUTWIN project (EU grant QLG2-CT-2002-01254).

PY - 2008/5

Y1 - 2008/5

N2 - Although caloric restriction in numerous models extends life, longevity in humans is suggested to be limited by the increased prevalence of obesity. Adiponectin, a fat-derived peptide, has a protective role against age-related disease, and thus is an excellent candidate gene for longevity. We studied adiponectin levels in centenarians (n = 118), their offspring (n = 228), and unrelated participants <95 (n = 78). Adiponectin levels were significantly greater in participants older than 95 years (p = .01), an effect that was independent of sex and body mass index (BMI). Adiponectin levels in the offspring were higher (following adjustment for age, sex, and BMI) compared to controls (p = .02), suggesting that inherited factors play a role in determining adiponectin levels. Over-representation of two common variants in Adiponectin gene (ADIPOQ) in male long-lived individuals combined with their independent association with elevated plasma adiponectin levels (in men and women) suggests that their presence may promote increased life span through the regulation of adiponectin production and/or secretion.

AB - Although caloric restriction in numerous models extends life, longevity in humans is suggested to be limited by the increased prevalence of obesity. Adiponectin, a fat-derived peptide, has a protective role against age-related disease, and thus is an excellent candidate gene for longevity. We studied adiponectin levels in centenarians (n = 118), their offspring (n = 228), and unrelated participants <95 (n = 78). Adiponectin levels were significantly greater in participants older than 95 years (p = .01), an effect that was independent of sex and body mass index (BMI). Adiponectin levels in the offspring were higher (following adjustment for age, sex, and BMI) compared to controls (p = .02), suggesting that inherited factors play a role in determining adiponectin levels. Over-representation of two common variants in Adiponectin gene (ADIPOQ) in male long-lived individuals combined with their independent association with elevated plasma adiponectin levels (in men and women) suggests that their presence may promote increased life span through the regulation of adiponectin production and/or secretion.

KW - Adiponectin

KW - Cardiovascular disease

KW - Genetics

KW - Longevity

KW - Metabolic syndrome

UR - http://www.scopus.com/inward/record.url?scp=47049090142&partnerID=8YFLogxK

U2 - 10.1093/gerona/63.5.447

DO - 10.1093/gerona/63.5.447

M3 - Article

C2 - 18511746

AN - SCOPUS:47049090142

SN - 1079-5006

VL - 63

SP - 447

EP - 453

JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

IS - 5

ER -

Adiponectin levels and genotype: A potential regulator of life span in humans

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this