Adherence to antipsychotic medication in schizophrenia patients

Vered Baloush-Kleinman, Michael Poyurovsky, Dany Koren, Michael Schneidman, Abraham Weizman, Dan Shnitt

Research output: Contribution to journalReview articlepeer-review


Antipsychotic agents are the mainstay of treatment for schizophrenia. However, almost 50% of schizophrenia patients exhibit non-compliance with antipsychotic drug therapy. This in turn may account for high relapse rate, reduced quality of life and increased burden on society. Identification of factors that may mediate adherence to treatment is therefore a primary clinical challenge. This paper reviews the literature regarding medication adherence among schizophrenia patients, with an emphasis on four groups of mediating factors: illness-related, patient-related, treatment-related and environmental-related factors. In addition, we describe a modified health-belief model that may facilitate better understanding of empirical findings. Therapeutic interventions to encourage better treatment compliance are discussed.

Original languageEnglish
Pages (from-to)1042-1049, 1090
Issue number12
StatePublished - Dec 2002
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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