Adaptive patterns in the p53 protein sequence of the hypoxia- and cancer-tolerant blind mole rat Spalax

Keyphrases

• Protein Sequence 100%
• Hypoxia 100%
• Spalax 100%
• Adaptation Pattern 100%
• Blind Mole Rat 100%
• P53 Protein 100%
• DNA Damage Response 75%
• Tolerant Species 50%
• Hypoxic Condition 50%
• Hypoxia-tolerant 50%
• Stress-related 25%
• Stress-induced 25%
• Adaptation 25%
• Transactivation 25%
• Phylogeny 25%
• DNA Damage 25%
• Oxygen Level 25%
• Oncogenesis 25%
• Shared Features 25%
• Long-lived 25%
• Evolutionary Adaptation 25%
• 3D Modeling 25%
• Coactivator 25%
• Tumor Protein p53 (TP53) 25%
• Anticancer 25%
• Hypoxic Stress 25%
• Species Identification 25%
• Extreme Environmental Conditions 25%
• Common Mechanisms 25%
• Master Regulator 25%
• DNA Repair Enzymes 25%
• P53 Transactivation 25%
• Regulatory Domain 25%
• P53 DNA 25%
• Dimerization Domain 25%
• Nannospalax 25%
• DNA Integrity 25%
• Critical DNA 25%
• Spontaneous Cancer 25%
• P300 25%
• Specific Positions 25%

Biochemistry, Genetics and Molecular Biology

• Peptide Sequence 100%
• P53 100%
• Spalax 100%
• DNA Damage Response 42%
• Transactivation 28%
• Evolutionary Adaptation 14%
• DNA Damage 14%
• Carcinogenesis 14%
• Anticancer 14%
• DNA Repair Protein 14%
• Cladistics 14%

Pharmacology, Toxicology and Pharmaceutical Science

• Malignant Neoplasm 100%
• Protein P53 100%
• Hypoxia 100%
• Spalax 100%
• Carcinogenesis 14%