Acute social isolation and regrouping cause short- and long-term molecular changes in the rat medial amygdala

Danit Lavenda-Grosberg, Maya Lalzar, Noam Leser, Aseel Yaseen, Assaf Malik, Mouna Maroun, Liza Barki-Harrington, Shlomo Wagner

Research output: Contribution to journalArticlepeer-review


Social isolation poses a severe mental and physiological burden on humans. Most animal models that investigate this effect are based on prolonged isolation, which does not mimic the milder conditions experienced by people in the real world. We show that in adult male rats, acute social isolation causes social memory loss. This memory loss is accompanied by significant changes in the expression of specific mRNAs and proteins in the medial amygdala, a brain structure that is crucial for social memory. These changes particularly involve the neurotrophic signaling and axon guidance pathways that are associated with neuronal network remodeling. Upon regrouping, memory returns, and most molecular changes are reversed within hours. However, the expression of some genes, especially those associated with neurodegenerative diseases remain modified for at least a day longer. These results suggest that acute social isolation and rapid resocialization, as experienced by millions during the COVID-19 pandemic, are sufficient to induce significant changes to neuronal networks, some of which may be pathological.

Original languageEnglish
Pages (from-to)886-895
Number of pages10
JournalMolecular Psychiatry
Issue number2
StatePublished - Feb 2022

Bibliographical note

Funding Information:
We thank Dr. Shai Netser and Dr. Shani Haskal de la Zerda for excellent technical assistance. This study was supported by The Human Frontier Science Program (HFSP grant RGP0019/2015 to SW), the Israel Science Foundation (ISF grants #1350/12, 1361/17 to SW and # 2240/19 to LBH), the Ministry of Science, Technology and Space of Israel (Grant #3-12068 to SW) and the United States-Israel Binational Science Foundation (BSF grant # 2019186 to SW).

Publisher Copyright:
© 2021, The Author(s).

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience


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