Peripheral benzodiazepine receptor (PBR) density has been found to be sensitive to stress. We set out to compare the influences of acute and repeated swim stress on behavior and PBR density. Following acute and repeated swim stress, rats were tested in an elevated plus-maze and an open-field test for anxiety levels, and tissues were collected from the adrenal gland, kidney, and hippocampus for measurements of PBR density. The acute rather than the repeated stress led to robust alterations in PBR density. The largest reduction in hippocampal and adrenal gland PBR density was found one hour after acute stress. In the hippocampus, acute stress caused a biphasic change in PBR density: a robust reduction in PBR density one hour after the acute stress and a distinct elevation in PBR density at 24 hours, while 72 hours after stress the elevation in PBR density appeared to be reduced.
Bibliographical noteFunding Information:
This work was supported by the V.P.R. Fund at the Technion-Israel Institute of Technology and the University of Haifa, Haifa, Israel. The Center for Absorption in Science, Ministry of Immigrant Absorption, State of Israel, is acknowledged for their support to S.L and L.V. We thank Ruth Singer for editing the manuscript.
- Peripheral benzodiazepine receptors
- Swim stress
ASJC Scopus subject areas
- Psychiatry and Mental health