Acute and repeated swim stress effects on peripheral benzodiazepine receptors in the rat hippocampus, adrenal, and kidney

Avi Avital; Gal Richter-Levin; Svetlana Leschiner; Ilana Spanier; Leo Veenman; Abraham Weizman; Moshe Gavish

doi:10.1016/S0893-133X(01)00286-X

Acute and repeated swim stress effects on peripheral benzodiazepine receptors in the rat hippocampus, adrenal, and kidney

Avi Avital, Gal Richter-Levin, Svetlana Leschiner, Ilana Spanier, Leo Veenman, Abraham Weizman, Moshe Gavish

Research output: Contribution to journal › Article › peer-review

Abstract

Peripheral benzodiazepine receptor (PBR) density has been found to be sensitive to stress. We set out to compare the influences of acute and repeated swim stress on behavior and PBR density. Following acute and repeated swim stress, rats were tested in an elevated plus-maze and an open-field test for anxiety levels, and tissues were collected from the adrenal gland, kidney, and hippocampus for measurements of PBR density. The acute rather than the repeated stress led to robust alterations in PBR density. The largest reduction in hippocampal and adrenal gland PBR density was found one hour after acute stress. In the hippocampus, acute stress caused a biphasic change in PBR density: a robust reduction in PBR density one hour after the acute stress and a distinct elevation in PBR density at 24 hours, while 72 hours after stress the elevation in PBR density appeared to be reduced.

Original language	English
Pages (from-to)	669-678
Number of pages	10
Journal	Neuropsychopharmacology
Volume	25
Issue number	5
DOIs	https://doi.org/10.1016/S0893-133X(01)00286-X
State	Published - 2001

Bibliographical note

Funding Information:
This work was supported by the V.P.R. Fund at the Technion-Israel Institute of Technology and the University of Haifa, Haifa, Israel. The Center for Absorption in Science, Ministry of Immigrant Absorption, State of Israel, is acknowledged for their support to S.L and L.V. We thank Ruth Singer for editing the manuscript.

Keywords

Anxiety
Peripheral benzodiazepine receptors
Stress
Swim stress

ASJC Scopus subject areas

Pharmacology
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S0893-133X(01)00286-X

Cite this

@article{d777b5a0a12d4c3ea5b7130b3b8609f5,

title = "Acute and repeated swim stress effects on peripheral benzodiazepine receptors in the rat hippocampus, adrenal, and kidney",

abstract = "Peripheral benzodiazepine receptor (PBR) density has been found to be sensitive to stress. We set out to compare the influences of acute and repeated swim stress on behavior and PBR density. Following acute and repeated swim stress, rats were tested in an elevated plus-maze and an open-field test for anxiety levels, and tissues were collected from the adrenal gland, kidney, and hippocampus for measurements of PBR density. The acute rather than the repeated stress led to robust alterations in PBR density. The largest reduction in hippocampal and adrenal gland PBR density was found one hour after acute stress. In the hippocampus, acute stress caused a biphasic change in PBR density: a robust reduction in PBR density one hour after the acute stress and a distinct elevation in PBR density at 24 hours, while 72 hours after stress the elevation in PBR density appeared to be reduced.",

keywords = "Anxiety, Peripheral benzodiazepine receptors, Stress, Swim stress",

author = "Avi Avital and Gal Richter-Levin and Svetlana Leschiner and Ilana Spanier and Leo Veenman and Abraham Weizman and Moshe Gavish",

note = "Funding Information: This work was supported by the V.P.R. Fund at the Technion-Israel Institute of Technology and the University of Haifa, Haifa, Israel. The Center for Absorption in Science, Ministry of Immigrant Absorption, State of Israel, is acknowledged for their support to S.L and L.V. We thank Ruth Singer for editing the manuscript.",

year = "2001",

doi = "10.1016/S0893-133X(01)00286-X",

language = "English",

volume = "25",

pages = "669--678",

journal = "Neuropsychopharmacology",

issn = "0893-133X",

publisher = "Nature Publishing Group",

number = "5",

}

TY - JOUR

T1 - Acute and repeated swim stress effects on peripheral benzodiazepine receptors in the rat hippocampus, adrenal, and kidney

AU - Avital, Avi

AU - Richter-Levin, Gal

AU - Leschiner, Svetlana

AU - Spanier, Ilana

AU - Veenman, Leo

AU - Weizman, Abraham

AU - Gavish, Moshe

N1 - Funding Information: This work was supported by the V.P.R. Fund at the Technion-Israel Institute of Technology and the University of Haifa, Haifa, Israel. The Center for Absorption in Science, Ministry of Immigrant Absorption, State of Israel, is acknowledged for their support to S.L and L.V. We thank Ruth Singer for editing the manuscript.

PY - 2001

Y1 - 2001

N2 - Peripheral benzodiazepine receptor (PBR) density has been found to be sensitive to stress. We set out to compare the influences of acute and repeated swim stress on behavior and PBR density. Following acute and repeated swim stress, rats were tested in an elevated plus-maze and an open-field test for anxiety levels, and tissues were collected from the adrenal gland, kidney, and hippocampus for measurements of PBR density. The acute rather than the repeated stress led to robust alterations in PBR density. The largest reduction in hippocampal and adrenal gland PBR density was found one hour after acute stress. In the hippocampus, acute stress caused a biphasic change in PBR density: a robust reduction in PBR density one hour after the acute stress and a distinct elevation in PBR density at 24 hours, while 72 hours after stress the elevation in PBR density appeared to be reduced.

AB - Peripheral benzodiazepine receptor (PBR) density has been found to be sensitive to stress. We set out to compare the influences of acute and repeated swim stress on behavior and PBR density. Following acute and repeated swim stress, rats were tested in an elevated plus-maze and an open-field test for anxiety levels, and tissues were collected from the adrenal gland, kidney, and hippocampus for measurements of PBR density. The acute rather than the repeated stress led to robust alterations in PBR density. The largest reduction in hippocampal and adrenal gland PBR density was found one hour after acute stress. In the hippocampus, acute stress caused a biphasic change in PBR density: a robust reduction in PBR density one hour after the acute stress and a distinct elevation in PBR density at 24 hours, while 72 hours after stress the elevation in PBR density appeared to be reduced.

KW - Anxiety

KW - Peripheral benzodiazepine receptors

KW - Stress

KW - Swim stress

UR - http://www.scopus.com/inward/record.url?scp=0034782826&partnerID=8YFLogxK

U2 - 10.1016/S0893-133X(01)00286-X

DO - 10.1016/S0893-133X(01)00286-X

M3 - Article

C2 - 11682250

AN - SCOPUS:0034782826

SN - 0893-133X

VL - 25

SP - 669

EP - 678

JO - Neuropsychopharmacology

JF - Neuropsychopharmacology

IS - 5

ER -

Acute and repeated swim stress effects on peripheral benzodiazepine receptors in the rat hippocampus, adrenal, and kidney

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this