Abstract
Memories of past events can be recalled long after the event, indicating stability. But new experiences are also integrated into existing memories, indicating plasticity. In the hippocampus, spatial representations are known to remain stable but have also been shown to drift over long periods of time. We hypothesized that experience, more than the passage of time, is the driving force behind representational drift. We compared the within-day stability of place cells’ representations in dorsal CA1 of the hippocampus of mice traversing two similar, familiar tracks for different durations. We found that the more time the animals spent actively traversing the environment, the greater the representational drift, regardless of the total elapsed time between visits. Our results suggest that spatial representation is a dynamic process, related to the ongoing experiences within a specific context, and is related to memory update rather than to passive forgetting.
| Original language | English |
|---|---|
| Pages (from-to) | 2348-2356.e5 |
| Journal | Neuron |
| Volume | 111 |
| Issue number | 15 |
| DOIs | |
| State | Published - 2 Aug 2023 |
| Externally published | Yes |
Bibliographical note
Funding Information:We thank Yaniv Ziv for reading and commenting on the manuscript and Dafna Antes for preparing the graphical abstract. This research was supported by the Israel Science Foundation (grants Nos. 2655/18 and 2183/21 to D.D. and 1442/21 to O.B.), by the German-Israeli Foundation (GIF I-1477-421.13/2018) to D.D. by a grant from the US-Israel Binational Science Foundation (NIMH-BSF CRCNS BSF:2019807, NIMH:R01 MH125544-01 to D.D.), by an HFSP research grant (RGP0017/2021) to O.B. by a Rappaport Institute Collaborative research grant to D.D. by Israel PBC-VATAT and by the Technion Center for Machine Learning and Intelligent Systems (MLIS) to D.D. and O.B. by the Prince Center for the Aging Brain, and by a University of Michigan – Israel Partnership for Research and Education Collaborative Research stipend to D.K. Conceptualization, D.K. A.R. O.B. G.M. and D.D.; methodology, D.K. A.R. G.M. and D.D.; software, D.K. and A.R.; formal analysis, D.K. and A.R.; investigation, D.K. and M.S.; resources, D.D.; data curation, D.K. and M.S.; writing – original draft, D.K. and A.R.; writing – review editing, G.M. D.D. and O.B.; visualization, D.K. and A.R.; supervision, G.M. and D.D.; project administration, G.M. and D.D.; funding acquisition, D.D. and O.B. The authors declare no competing interests. We support inclusive, diverse, and equitable conduct of research.
Funding Information:
We thank Yaniv Ziv for reading and commenting on the manuscript and Dafna Antes for preparing the graphical abstract. This research was supported by the Israel Science Foundation (grants Nos. 2655/18 and 2183/21 to D.D., and 1442/21 to O.B.), by the German-Israeli Foundation ( GIF I-1477-421.13/2018 ) to D.D., by a grant from the US-Israel Binational Science Foundation ( NIMH - BSF CRCNS BSF :2019807, NIMH : R01 MH125544-01 to D.D.), by an HFSP research grant ( RGP0017/2021 ) to O.B., by a Rappaport Institute Collaborative research grant to D.D., by Israel PBC-VATAT and by the Technion Center for Machine Learning and Intelligent Systems (MLIS) to D.D. and O.B., by the Prince Center for the Aging Brain , and by a University of Michigan – Israel Partnership for Research and Education Collaborative Research stipend to D.K.
Publisher Copyright:
© 2023 Elsevier Inc.
Keywords
- CA1
- hippocampus
- one-photon Ca2+ imaging
- place cells
- reconsolidation
- remapping
- representational drift
ASJC Scopus subject areas
- Neuroscience (all)