@inbook{52f90baab5f34bf0b97825db95ce12e9,
title = "Actions of norepinephrine in the rat hippocampus",
abstract = "Acting at postsynaptic α1- and β1-receptors, norepinephrine (NE) exerts a complex action in rat hippocampus. It is currently believed that β1-receptor activation enhances excitability of recorded neurons, whereas α1 activation suppresses reactivity to afferent stimulation. These reported effects of α-agonists are not consistent with α1 effects found elsewhere in the brain. We have conducted experiments in the anesthetized rat and found that an amphetamine-induced increase in the dentate gyrus population spike can be blocked by a β-antagonist but also by an α1-antagonist. We have conducted experiments in the brain slide preparation and found that an α-agonist, phenylephrine (PHE), selectively enhances responses to N-methyl-D-aspartate (NMDA) but not to quisqualate. We propose that the product of activation of both α- and β-receptor types will enhance reactivity of hippocampal cells to afferent stimulation.",
keywords = "dentate gyrus, hippocampus, norepinephrine, α-receptor",
author = "M. Segal and H. Markram and G. Richter-Levin",
year = "1991",
month = jan,
day = "1",
doi = "10.1016/S0079-6123(08)63819-4",
language = "English",
series = "Progress in Brain Research",
number = "C",
pages = "323--330",
booktitle = "Progress in Brain Research",
edition = "C",
}