Actin polymerization in lateral amygdala is essential for fear memory formation

Lilach Mantzur, Gil Joels, Raphael Lamprecht

Research output: Contribution to journalArticlepeer-review


Actin polymerization is involved in key neuronal functions such as intracellular trafficking and morphogenesis. In this study, we examined the role of actin polymerization in lateral amygdala (LA) in fear conditioning memory formation. Microinfusion of cytochalasin D, an actin polymerization inhibitor, into rat LA immediately before fear conditioning training impaired the formation of long-term fear memory (LTM) but not short-term fear memory (STM). Microinfusion of cytochalasin D into rat LA immediately after fear conditioning impaired LTM. Cytochalasin D had no effect on fear conditioning memory retrieval when injected immediately before LTM test. These results show that actin cytoskeleton rearrangement is essential for fear memory consolidation.

Original languageEnglish
Pages (from-to)85-88
Number of pages4
JournalNeurobiology of Learning and Memory
Issue number1
StatePublished - Jan 2009


  • Actin cytoskeleton
  • Amygdala
  • Fear conditioning
  • Memory

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience


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