Absorption pathways of amino acids in the midgut of Manduca sexta larvae

Moshe Reuveni, Peter E. Dunn

Research output: Contribution to journalArticlepeer-review


The unidirectional transport of leucine and aspartic acid by midgut epithelium cells of the tobacco ornworm, Manduca sexta, was investigated using brush border membrane vesicles. Both K+-stimulated and K+-insensitive transport pathways for these two amino acids were identified. Kinetic analyses and profiles of cis-inhibition by other amino acids demonstrated that leucine and aspartic acid are transported by separate pathways and exhibit different sensitivity to potassium ion.

Original languageEnglish
Pages (from-to)959-966
Number of pages8
JournalInsect Biochemistry and Molecular Biology
Issue number8
StatePublished - Dec 1993
Externally publishedYes

Bibliographical note

Funding Information:
Several pathways that transport different amino acids, such as phenylalanine, histidine, glutamic acid, lysine and alanine, have been described in midgut brush border membrane vesicles (BBMV) from Pieris brassicae *This research was supported by USDA Competitive Research Grant No. 88-37153-4098 to P. E. Dunn. This is journal paper No. 12641 from the Indiana Agricultural Experiment Station. tDepartment of Entomology,1 158 EntomologyH all, Purdue Univer-sity, West Lafayette,I N 47907-1158, U.S.A. :~Author for correspondence.


  • Amino acid transport
  • Brush border membrane vesicle
  • Manduca sexta
  • Midgut epithelium

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Insect Science


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